Titre

Cancer: Linking Powerhouses to Suicidal Bags.

Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Martinez-Carreres, L.
Auteure/Auteur
Nasrallah, A.
Auteure/Auteur
Fajas, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2234-943X
Statut éditorial
Publié
Date de publication
2017
Volume
7
Première page
204
Peer-reviewed
Oui
Langue
anglais
Résumé
Membrane-bound organelles are integrated into cellular networks and work together for a common goal: regulating cell metabolism, cell signaling pathways, cell fate, cellular maintenance, and pathogen defense. Many of these interactions are well established, but little is known about the interplay between mitochondria and lysosomes, and their deregulation in cancer. The present review focuses on the common signaling pathways of both organelles, as well as the processes in which they both physically interact, their changes under pathological conditions, and the impact on targeting those organelles for treating cancer.
Sujets

AMP-activated protein...

Rab7

cancer

lysosomal membrane pe...

lysosomes

mammalian target of r...

mitochondria

mitophagy

PID Serval
serval:BIB_030409EABA61
DOI
PMID
WOS
Permalien
Open Access
Oui
Date de création
2017-10-09T08:30:38.481Z
Date de création dans IRIS
2025-05-20T19:59:10Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

28932704_BIB_030409EABA61.pdf

Version du manuscrit

published

Taille

864.35 KB

Format

Adobe PDF

PID Serval

serval:BIB_030409EABA61.P001

URN

urn:nbn:ch:serval-BIB_030409EABA611

Somme de contrôle

(MD5):c56bdf3f2d2626bc914f996e04b360a3