Titre
Metabolic interplay: tumor macrophages and regulatory T cells.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Vilbois, S.
Auteure/Auteur
Xu, Y.
Auteure/Auteur
Ho, P.C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2405-8025
Statut éditorial
Publié
Date de publication
2024-03
Volume
10
Numéro
3
Première page
242
Dernière page/numéro d’article
255
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
The tumor microenvironment (TME) contains a complex cellular ecosystem where cancer, stromal, vascular, and immune cells interact. Macrophages and regulatory T cells (Tregs) are critical not only for maintaining immunological homeostasis and tumor growth but also for monitoring the functional states of other immune cells. Emerging evidence reveals that metabolic changes in macrophages and Tregs significantly influence their pro-/antitumor functions through the regulation of signaling cascades and epigenetic reprogramming. Hence, they are increasingly recognized as therapeutic targets in cancer immunotherapy. Specific metabolites in the TME may also affect their pro-/antitumor functions by intervening with the metabolic machinery. We discuss how metabolites influence the immunosuppressive phenotypes of tumor-associated macrophages (TAMs) and Tregs. We then describe how TAMs and Tregs, independently or collaboratively, utilize metabolic mechanisms to suppress the activity of CD8 <sup>+</sup> T cells. Finally, we highlight promising metabolic interventions that can improve the outcome of current cancer therapies.
PID Serval
serval:BIB_0E0F7603EBDF
PMID
Date de création
2024-01-10T10:03:31.658Z
Date de création dans IRIS
2025-05-20T13:45:17Z