Titre
Virus-like particles induce robust human T-helper cell responses.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Braun, M.
Auteure/Auteur
Jandus, C.
Auteure/Auteur
Maurer, P.
Auteure/Auteur
Hammann-Haenni, A.
Auteure/Auteur
Schwarz, K.
Auteure/Auteur
Bachmann, M.F.
Auteure/Auteur
Speiser, D.E.
Auteure/Auteur
Romero, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1521-4141
Statut éditorial
Publié
Date de publication
2012
Volume
42
Numéro
2
Première page
330
Dernière page/numéro d’article
340
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Among synthetic vaccines, virus-like particles (VLPs) are used for their ability to induce strong humoral responses. Very little is reported on VLP-based-vaccine-induced CD4(+) T-cell responses, despite the requirement of helper T cells for antibody isotype switching. Further knowledge on helper T cells is also needed for optimization of CD8(+) T-cell vaccination. Here, we analysed human CD4(+) T-cell responses to vaccination with MelQbG10, which is a Qβ-VLP covalently linked to a long peptide derived from the melanoma self-antigen Melan-A. In all analysed patients, we found strong antibody responses of mainly IgG1 and IgG3 isotypes, and concomitant Th1-biased CD4(+) T-cell responses specific for Qβ. Although less strong, comparable B- and CD4(+) T-cell responses were also found specific for the Melan-A cargo peptide. Further optimization is required to shift the response more towards the cargo peptide. Nevertheless, the data demonstrate the high potential of VLPs for inducing humoral and cellular immune responses by mounting powerful CD4(+) T-cell help.
PID Serval
serval:BIB_6CC8896DD5F6
PMID
Open Access
Oui
Date de création
2012-02-16T13:58:20.811Z
Date de création dans IRIS
2025-05-21T01:32:45Z