Titre
Plasmodium falciparum: extensive polymorphism in merozoite surface antigen 2 alleles in an area with endemic malaria in Papua New Guinea
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Felger, I.
Auteure/Auteur
Tavul, L.
Auteure/Auteur
Kabintik, S.
Auteure/Auteur
Marshall, V.
Auteure/Auteur
Genton, B.
Auteure/Auteur
Alpers, M.
Auteure/Auteur
Beck, H. P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0014-4894
Statut éditorial
Publié
Date de publication
1994-09
Volume
79
Numéro
2
Première page
106
Dernière page/numéro d’article
16
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Sep
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Sep
Résumé
Plasmodium falciparum: Extensive polymorphism in merozoite surface antigen 2 alleles in an area with endemic malaria in Papua New Guinea. Experimental Parasitology 79, 106-116. The prevalence of Plasmodium falciparum in 304 individuals from two villages in Papua New Guinea has been determined by PCR amplification of the gene encoding the merozoite surface antigen 2 (MSA2). Forty-seven percent of the blood samples were positive for P. falciparum. The MSA2 alleles of this parasite population were characterized by PCR-RFLP genotyping. In 144 P. falciparum infections 38 different MSA2 alleles were found. The most common allele (22%) was a variant of FC27. Further alleles, found in the study area, were IC1, KF1916, and MAD71. In addition to these previously described alleles, 33 novel variant forms of MSA2 were detected, most of which were represented at very low frequency in the study population. MSA2 genotyping of a local P. falciparum population revealed an unexpected amount of genetic heterogeneity. The diversity is mostly due to variation in the repeat region resulting in length polymorphism that can be easily detected by PCR-RFLP.
Sujets
PID Serval
serval:BIB_DE9E9ECE8AE1
PMID
Date de création
2008-01-28T10:48:47.429Z
Date de création dans IRIS
2025-05-21T06:30:25Z