Titre
Photodynamic therapy for polypoidal choroidal vasculopathy.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Nowak-Sliwinska, P.
Auteure/Auteur
van den Bergh, H.
Auteure/Auteur
Sickenberg, M.
Auteure/Auteur
Koh, A.H.
Auteure/Auteur
Liens vers les unités
ISSN
1873-1635
Statut éditorial
Publié
Date de publication
2013
Volume
37
Première page
182
Dernière page/numéro d’article
199
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The first effective therapy for exudative macular degeneration (AMD) was Photodynamic Therapy (PDT). Diagnosis of the disease was to a large extent by fluorescein angiography (FA). Distinguishing between the leaky choroidal neovessels (CNV) associated with exudative AMD, and the polypoidal structures associated with Polypoidal Choroidal Vasculopathy (PCV) is not always easy using FA alone. The switch to Indocyanine Green angiography helped to pinpoint PCV, and thus to study the efficacy of photodynamic therapy of this particular form of retinal disease, which is more frequently encountered among pigmented individuals. The results appear to be quite promising, and in the year following treatment only a small fraction of the patients had to be retreated. Alternatively, treating PCV with repeated intravitreal VEGF blocking agents was not as successful as it was in the treatment of wet AMD. However, combining PDT-induced angio-occlusion of the polypoidal lesions with anti-vascular endothelial growth factor therapy was shown to be quite effective, and the combination of PDT with an anti-angiogenic agent as well as a steroid, in a triple therapy, was recently also shown to be a quite promising option. In the present article we review the data on PDT of PCV, including combination therapies and alternative treatments. We also report on similarities and differences between AMD and PCV.
PID Serval
serval:BIB_E1CB640EAE52
PMID
Open Access
Oui
Date de création
2014-01-03T08:42:16.570Z
Date de création dans IRIS
2025-05-20T22:52:50Z