Titre
Sex Differences and Functional Outcome After Intravenous Thrombolysis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Spaander, F.H.
Auteure/Auteur
Zinkstok, S.M.
Auteure/Auteur
Baharoglu, I.M.
Auteure/Auteur
Gensicke, H.
Auteure/Auteur
Polymeris, A.
Auteure/Auteur
Traenka, C.
Auteure/Auteur
Hametner, C.
Auteure/Auteur
Ringleb, P.
Auteure/Auteur
Curtze, S.
Auteure/Auteur
Martinez-Majander, N.
Auteure/Auteur
Aarnio, K.
Auteure/Auteur
Nolte, C.H.
Auteure/Auteur
Scheitz, J.F.
Auteure/Auteur
Leys, D.
Auteure/Auteur
Hochart, A.
Auteure/Auteur
Padjen, V.
Auteure/Auteur
Kägi, G.
Auteure/Auteur
Pezzini, A.
Auteure/Auteur
Michel, P.
Auteure/Auteur
Bill, O.
Auteure/Auteur
Zini, A.
Auteure/Auteur
Engelter, S.T.
Auteure/Auteur
Nederkoorn, P.J.
Auteure/Auteur
Groupes de travail
Thrombolysis in Ischemic Stroke Patients Collaborators (TrISP)
Liens vers les personnes
Liens vers les unités
ISSN
1524-4628
Statut éditorial
Publié
Date de publication
2017-03
Volume
48
Numéro
3
Première page
699
Dernière page/numéro d’article
703
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Women have a worse outcome after stroke compared with men, although in intravenous thrombolysis (IVT)-treated patients, women seem to benefit more. Besides sex differences, age has also a possible effect on functional outcome. The interaction of sex on the functional outcome in IVT-treated patients in relation to age remains complex. The purpose of this study was to compare outcome after IVT between women and men with regard to age in a large multicenter European cohort reflecting daily clinical practice of acute stroke care.
Data were obtained from IVT registries of 12 European tertiary hospitals. The primary outcome was poor functional outcome, defined as a modified Rankin scale score of 3 to 6 at 3 months. We stratified outcome by age in decades. Safety measures were symptomatic intracranial hemorrhage and mortality at 3 months.
In this cohort, 9495 patients were treated with IVT, and 4170 (43.9%) were women with a mean age of 71.9 years. After adjustments for baseline differences, female sex remained associated with poor functional outcome (odds ratio, 1.15; 95% confidence interval, 1.02-1.31). There was no association between sex and functional outcome when data were stratified by age. Symptomatic intracranial hemorrhage rate was similar in both sexes (adjusted odds ratio, 0.93; 95% confidence interval, 0.73-1.19), whereas mortality was lower among women (adjusted odds ratio, 0.83; 95% confidence interval, 0.70-0.99).
In this large cohort of IVT-treated patients, women more often had poor functional outcome compared with men. This difference was not dependent on age.
Data were obtained from IVT registries of 12 European tertiary hospitals. The primary outcome was poor functional outcome, defined as a modified Rankin scale score of 3 to 6 at 3 months. We stratified outcome by age in decades. Safety measures were symptomatic intracranial hemorrhage and mortality at 3 months.
In this cohort, 9495 patients were treated with IVT, and 4170 (43.9%) were women with a mean age of 71.9 years. After adjustments for baseline differences, female sex remained associated with poor functional outcome (odds ratio, 1.15; 95% confidence interval, 1.02-1.31). There was no association between sex and functional outcome when data were stratified by age. Symptomatic intracranial hemorrhage rate was similar in both sexes (adjusted odds ratio, 0.93; 95% confidence interval, 0.73-1.19), whereas mortality was lower among women (adjusted odds ratio, 0.83; 95% confidence interval, 0.70-0.99).
In this large cohort of IVT-treated patients, women more often had poor functional outcome compared with men. This difference was not dependent on age.
Sujets
PID Serval
serval:BIB_BA13D0E88F1E
PMID
Open Access
Oui
Date de création
2017-02-07T16:58:08.591Z
Date de création dans IRIS
2025-05-21T00:17:04Z