Titre
Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Mehra, T.
Auteure/Auteur
Grözinger, G.
Auteure/Auteur
Mann, S.
Auteure/Auteur
Guenova, E.
Auteure/Auteur
Moos, R.
Auteure/Auteur
Röcken, M.
Auteure/Auteur
Claussen, C.D.
Auteure/Auteur
Dummer, R.
Auteure/Auteur
Clasen, S.
Auteure/Auteur
Naumann, A.
Auteure/Auteur
Garbe, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1932-6203
Statut éditorial
Publié
Date de publication
2014
Volume
9
Numéro
11
Première page
e112535
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Data on survival with mucosal melanoma and on prognostic factors of are scarce. It is still unclear if the disease course allows for mucosal melanoma to be treated as primary cutaneous melanoma or if differences in overall survival patterns require adapted therapeutic approaches. Furthermore, this investigation is the first to present 10-year survival rates for mucosal melanomas of different anatomical localizations.
116 cases from Sep 10 1984 until Feb 15 2011 retrieved from the Comprehensive Cancer Center and of the Central Register of the German Dermatologic Society databases in Tübingen were included in our analysis. We recorded anatomical location and tumor thickness, and estimated overall survival at 2, 5 and 10 years and the mean overall survival time. Survival times were analyzed with the Kaplan-Meier method. The log-rank test was used to compare survival times by localizations and by T-stages.
We found a median overall survival time of 80.9 months, with an overall 2-year survival of 71.7%, 5-year survival of 55.8% and 10-year survival of 38.3%. The 10-year survival rates for patients with T1, T2, T3 or T4 stage tumors were 100.0%, 77.9%, 66.3% and 10.6% respectively. 10-year survival of patients with melanomas of the vulva was 64.5% in comparison to 22.3% of patients with non-vulva mucosal melanomas.
Survival times differed significantly between patients with melanomas of the vulva compared to the rest (p = 0.0006). It also depends on T-stage at the time of diagnosis (p < 0.0001).
116 cases from Sep 10 1984 until Feb 15 2011 retrieved from the Comprehensive Cancer Center and of the Central Register of the German Dermatologic Society databases in Tübingen were included in our analysis. We recorded anatomical location and tumor thickness, and estimated overall survival at 2, 5 and 10 years and the mean overall survival time. Survival times were analyzed with the Kaplan-Meier method. The log-rank test was used to compare survival times by localizations and by T-stages.
We found a median overall survival time of 80.9 months, with an overall 2-year survival of 71.7%, 5-year survival of 55.8% and 10-year survival of 38.3%. The 10-year survival rates for patients with T1, T2, T3 or T4 stage tumors were 100.0%, 77.9%, 66.3% and 10.6% respectively. 10-year survival of patients with melanomas of the vulva was 64.5% in comparison to 22.3% of patients with non-vulva mucosal melanomas.
Survival times differed significantly between patients with melanomas of the vulva compared to the rest (p = 0.0006). It also depends on T-stage at the time of diagnosis (p < 0.0001).
PID Serval
serval:BIB_7DFCAAE42EAE
PMID
URL éditeur
Open Access
Oui
Date de création
2020-08-27T12:59:54.824Z
Date de création dans IRIS
2025-05-21T03:19:59Z
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25383553_BIB_7DFCAAE42EAE.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
486.04 KB
Format
Adobe PDF
PID Serval
serval:BIB_7DFCAAE42EAE.P001
URN
urn:nbn:ch:serval-BIB_7DFCAAE42EAE0
Somme de contrôle
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