Titre
Percentage, bacterial etiology and antibiotic susceptibility of acute respiratory infection and pneumonia among children in rural Senegal
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Echave, P.
Auteure/Auteur
Bille, J.
Auteure/Auteur
Audet, C.
Auteure/Auteur
Talla, I.
Auteure/Auteur
Vaudaux, B.
Auteure/Auteur
Gehri, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0142-6338
Statut éditorial
Publié
Date de publication
2003-02
Volume
49
Numéro
1
Première page
28
Dernière page/numéro d’article
32
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
Acute respiratory infections (ARI) are still a major health problem in most developing countries. So far no study has evaluated the importance of childhood ARI in rural Senegal. We prospectively studied ARI, the percentage of pneumonia and related mortality, as well as the bacterial composition of nasopharyngeal flora using nasopharyngeal aspirates in 114 children, aged 2-59 months, presenting at Ndioum's pediatric ward. Excluded from the trial were those children that had had antimicrobial therapy in the previous 2 weeks. The Kirby-Bauer method was used to determine antibiotic resistance throughout the study. The percentage of ARI and pneumonia among the population tested was 24 per cent and 11 per cent respectively. Streptococcus pneumonia was often resistant to cotrimoxazole (31 per cent) but only 9 per cent were resistant to chloramphenicol and 14 per cent to penicillin. Haemophilus influenzae (HI) was uniformly sensitive to ampicillin, and only 4 per cent were resistant to chloramphenicol and 11 per cent to cotrimoxazole. We conclude that SP and HI resistance to cotrimoxazole is important and warrants larger clinical trials using chloramphenicol. Information campaigns and intense management of comorbidities are desirable in this type of population. Comorbidities (tuberculosis, malaria, HIV-AIDS, severe malnutrition) are determinant variables in many ARI cases and carry a high negative prognosis value.
Sujets
PID Serval
serval:BIB_733012D68E66
PMID
Open Access
Oui
Date de création
2008-01-25T09:33:22.101Z
Date de création dans IRIS
2025-05-20T23:03:22Z
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Nom
REF.pdf
Version du manuscrit
published
Taille
60.47 KB
Format
Adobe PDF
PID Serval
serval:BIB_733012D68E66.P001
URN
urn:nbn:ch:serval-BIB_733012D68E662
Somme de contrôle
(MD5):c24c08e52cc575b3bf1cd30a9d211b2d