Titre
A-kinase anchoring proteins: Molecular regulators of the cardiac stress response
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Diviani, Dario
Auteure/Auteur
Maric, Darko
Auteure/Auteur
Pérez López, Irene
Auteure/Auteur
Cavin, Sabrina
Auteure/Auteur
del Vescovo, Cosmo D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0167-4889
Statut éditorial
Publié
Date de publication
2013-04
Volume
1833
Numéro
4
Première page
901
Dernière page/numéro d’article
908
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish; PDF : review
Résumé
In response to stress or injury the heart undergoes a pathological remodeling process, associated with hypertrophy, cardiomyocyte death and fibrosis, that ultimately causes cardiac dysfunction and heart failure. It has become increasingly clear that signaling events associated with these pathological cardiac remodeling events are regulated by scaffolding and anchoring proteins, which allow coordination of pathological signals in space and time. A-kinase anchoring proteins (AKAPs) constitute a family of functionally related proteins that organize multiprotein signaling complexes that tether the cAMP-dependent protein kinase (PKA) as well as other signaling enzymes to ensure integration and processing of multiple signaling pathways. This review will discuss the role of AKAPs in the cardiac response to stress. Particular emphasis will be given to the adaptative process associated with cardiac hypoxia as well as the remodeling events linked to cardiac hypertrophy and heart failure. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Cardiac Pathways of Differentiation, Metabolism and Contraction.
PID Serval
serval:BIB_939EDC045F5A
PMID
Open Access
Oui
Date de création
2013-04-21T07:27:50.345Z
Date de création dans IRIS
2025-05-21T03:44:19Z