Titre
Non-ischemic cerebral enhancing lesions after intracranial aneurysm endovascular repair: a retrospective French national registry.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Shotar, E.
Auteure/Auteur
Labeyrie, M.A.
Auteure/Auteur
Biondi, A.
Auteure/Auteur
Velasco, S.
Auteure/Auteur
Saliou, G.
Auteure/Auteur
Boulouis, G.
Auteure/Auteur
Daumas-Duport, B.
Auteure/Auteur
Bourcier, R.
Auteure/Auteur
Janot, K.
Auteure/Auteur
Herbreteau, D.
Auteure/Auteur
Michelozzi, C.
Auteure/Auteur
Premat, K.
Auteure/Auteur
Redjem, H.
Auteure/Auteur
Bricout, N.
Auteure/Auteur
Thouant, P.
Auteure/Auteur
Arteaga, C.
Auteure/Auteur
Pierot, L.
Auteure/Auteur
Tahon, F.
Auteure/Auteur
Boubagra, K.
Auteure/Auteur
Ikka, L.
Auteure/Auteur
Chabert, E.
Auteure/Auteur
Lenck, S.
Auteure/Auteur
Guédon, A.
Auteure/Auteur
Consoli, A.
Auteure/Auteur
Saleme, S.
Auteure/Auteur
di Maria, F.
Auteure/Auteur
Ferré, J.C.
Auteure/Auteur
Eugene, F.
Auteure/Auteur
Anxionnat, R.
Auteure/Auteur
Marnat, G.
Auteure/Auteur
Guetarni, Z.
Auteure/Auteur
Sourour, N.A.
Auteure/Auteur
Dormont, D.
Auteure/Auteur
Clarençon, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1759-8486
Statut éditorial
Publié
Date de publication
2022-09
Volume
14
Numéro
9
Première page
925
Dernière page/numéro d’article
930
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Non-ischemic cerebral enhancing (NICE) lesions are exceptionally rare following aneurysm endovascular therapy (EVT).
To investigate the presenting features and longitudinal follow-up of patients with NICE lesions following aneurysm EVT.
Patients included in a retrospective national multicentre inception cohort were analysed. NICE lesions were defined, using MRI, as delayed onset punctate, nodular or annular foci enhancements with peri-lesion edema, distributed in the vascular territory of the aneurysm EVT, with no other confounding disease.
From a pool of 58 815 aneurysm endovascular treatment procedures during the study sampling period (2006-2019), 21/37 centres identified 31 patients with 32 aneurysms of the anterior circulation who developed NICE lesions (mean age 45±10 years). Mean delay to diagnosis was 5±9 months, with onset occurring a month or less after the index EVT procedure in 10 out of 31 patients (32%). NICE lesions were symptomatic at time of onset in 23 of 31 patients (74%). After a mean follow-up of 25±26 months, 25 patients (81%) were asymptomatic or minimally symptomatic without disability (modified Rankin Scale (mRS) score 0-1) at last follow-up while 4 (13%) presented with mild disability (mRS score 2). Clinical follow-up data were unavailable for two patients. Follow-up MRI (available in 27 patients; mean time interval after onset of 22±22 months) demonstrated persistent enhancement in 71% of cases.
The clinical spectrum of NICE lesions following aneurysm EVT therapy spans a wide range of neurological symptoms. Clinical course is most commonly benign, although persistent long-term enhancement is frequent.
To investigate the presenting features and longitudinal follow-up of patients with NICE lesions following aneurysm EVT.
Patients included in a retrospective national multicentre inception cohort were analysed. NICE lesions were defined, using MRI, as delayed onset punctate, nodular or annular foci enhancements with peri-lesion edema, distributed in the vascular territory of the aneurysm EVT, with no other confounding disease.
From a pool of 58 815 aneurysm endovascular treatment procedures during the study sampling period (2006-2019), 21/37 centres identified 31 patients with 32 aneurysms of the anterior circulation who developed NICE lesions (mean age 45±10 years). Mean delay to diagnosis was 5±9 months, with onset occurring a month or less after the index EVT procedure in 10 out of 31 patients (32%). NICE lesions were symptomatic at time of onset in 23 of 31 patients (74%). After a mean follow-up of 25±26 months, 25 patients (81%) were asymptomatic or minimally symptomatic without disability (modified Rankin Scale (mRS) score 0-1) at last follow-up while 4 (13%) presented with mild disability (mRS score 2). Clinical follow-up data were unavailable for two patients. Follow-up MRI (available in 27 patients; mean time interval after onset of 22±22 months) demonstrated persistent enhancement in 71% of cases.
The clinical spectrum of NICE lesions following aneurysm EVT therapy spans a wide range of neurological symptoms. Clinical course is most commonly benign, although persistent long-term enhancement is frequent.
PID Serval
serval:BIB_582CEAE7E6DE
PMID
Date de création
2021-09-27T08:06:53.779Z
Date de création dans IRIS
2025-05-20T20:50:12Z