Titre
Acute toxicity of conventional radiation therapy for high-risk prostate cancer in EORTC trial 22863
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Zurlo, A.
Auteure/Auteur
Collette, L.
Auteure/Auteur
van Tienhoven, G.
Auteure/Auteur
Blank, L.
Auteure/Auteur
Warde, P.
Auteure/Auteur
Dubois, J.
Auteure/Auteur
Jeanneret, W.
Auteure/Auteur
Storme, G.
Auteure/Auteur
Bernier, J.
Auteure/Auteur
Kuten, A.
Auteure/Auteur
Pierart, M.
Auteure/Auteur
Bolla, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0302-2838
Statut éditorial
Publié
Date de publication
2002-08
Volume
42
Numéro
2
Première page
125
Dernière page/numéro d’article
32
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Aug
Résumé
OBJECTIVES: We analysed the acute toxicity observed in the European Organisation for Research and Treatment of Cancer (EORTC) randomised trial 22863 comparing conventional external irradiation with or without an agonist analogue of gonadotropin-releasing hormone in high-risk prostate cancer patients.METHODS: Four hundred five patients that received a dose of at least 30 Gy were considered evaluable for acute toxicity assessment. Toxicity was grouped in a few categories: general, genito-urinary, and lower gastro-intestinal. Univariate and multivariate analyses were performed using the World Health Organisation (WHO) toxicity score and grouping together toxicity scores in different bimodal and trimodal groups.RESULTS: Overall, our data show that age, previous surgery and irradiation dose are important predictive factors for acute toxicity, but not the use of combined hormone therapy. Fifteen percent of patients suffered of moderate to severe acute toxicity (WHO G3-G4). Life threatening toxicity was observed in six cases (1.5%).CONCLUSIONS: The assessment of toxicity combining in different groups the original five scores scale produced conflicting results similar to those commonly reported in literature. Interpretation of the role of pre-treatment factors with uneven distribution in the study requires careful evaluation. These data obtained with conventional curative irradiation of high-risk prostate cancer patients are proposed for comparison with results achieved using modern state-of-the-art irradiation techniques.
Sujets
PID Serval
serval:BIB_359BA0A666F5
PMID
Date de création
2008-01-24T16:09:14.221Z
Date de création dans IRIS
2025-05-20T16:30:04Z