Titre
Post-allogeneic haematopoietic stem cell transplantation membranous nephropathy: clinical presentation, outcome and pathogenic aspects
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Terrier, B.
Auteure/Auteur
Delmas, Y.
Auteure/Auteur
Hummel, A.
Auteure/Auteur
Presne, C.
Auteure/Auteur
Glowacki, F.
Auteure/Auteur
Knebelmann, B.
Auteure/Auteur
Combe, C.
Auteure/Auteur
Lesavre, P.
Auteure/Auteur
Maillard, N.
Auteure/Auteur
Noel, L. H.
Auteure/Auteur
Patey-Mariaud de Serre, N.
Auteure/Auteur
Nusbaum, S.
Auteure/Auteur
Radford, I.
Auteure/Auteur
Buzyn, A.
Auteure/Auteur
Fakhouri, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0931-0509
Statut éditorial
Publié
Date de publication
2007-05
Volume
22
Numéro
5
Première page
1369
Dernière page/numéro d’article
76
Langue
anglais
Notes
Terrier, Benjamin
Delmas, Yahsou
Hummel, Aurelie
Presne, Claire
Glowacki, Francois
Knebelmann, Bertrand
Combe, Christian
Lesavre, Philippe
Maillard, Natacha
Noel, Laure-Helene
Patey-Mariaud de Serre, Natahlie
Nusbaum, Sylvie
Radford, Isabelle
Buzyn, Agnes
Fakhouri, Fadi
eng
Case Reports
England
Nephrol Dial Transplant. 2007 May;22(5):1369-76. doi: 10.1093/ndt/gfl795. Epub 2007 Jan 25.
Delmas, Yahsou
Hummel, Aurelie
Presne, Claire
Glowacki, Francois
Knebelmann, Bertrand
Combe, Christian
Lesavre, Philippe
Maillard, Natacha
Noel, Laure-Helene
Patey-Mariaud de Serre, Natahlie
Nusbaum, Sylvie
Radford, Isabelle
Buzyn, Agnes
Fakhouri, Fadi
eng
Case Reports
England
Nephrol Dial Transplant. 2007 May;22(5):1369-76. doi: 10.1093/ndt/gfl795. Epub 2007 Jan 25.
Résumé
BACKGROUND: Post-allogeneic haematopoietic stem cell transplantation (HSCT) membranous nephropathy (MN), a rare complication of HSCT, remains an ill-defined entity. We describe the clinical and biological characteristics and outcome of five patients with post-HSCT MN, review the previously reported cases and discuss the pathogenic aspects of this nephropathy. METHODS: Cases were identified by using a questionnaire sent to nephrologists and pathologists in French university and general hospitals. Medical records and kidney biopsy specimens were reviewed and relevant data were collected. Moreover, the IgG subclasses in glomerular deposits and the presence of chimeric renal cells were studied. RESULTS: Five patients were identified. All had a history of chronic graft-vs-host disease (cGVHD) and all had active manifestations of cGVHD at MN diagnosis. Mean time between HSCT and diagnosis of MN was 24.4 months. Renal insufficiency was present in four patients. Renal biopsy examination showed typical features of MN in all patients. IgG1 and IgG4 were the predominant IgG subclasses in the glomerular deposits. No chimeric glomerular cell was detected. Initial treatment for MN consisted in corticosteroids and immunosuppressors (ciclosporin, mycophenolate mofetil, rituximab, chlorambucil) in all patients. Complete remission of nephrotic syndrome (NS) occurred in two patients, partial remission in one patient, while treatment was inefficacious in one (data not available for one patient). Most interestingly, the evolution of NS paralleled the evolution of cGVHD in all patients. CONCLUSION: Our data suggest an association between cGVHD and post-HSCT MN. Treatment, mainly steroids and ciclosporin, should be aimed at the control of acute manifestations of cGVHD.
PID Serval
serval:BIB_D4533BB4F629
PMID
Date de création
2022-03-01T09:18:23.274Z
Date de création dans IRIS
2025-05-20T23:58:59Z