Titre

Mitoclone2: an R package for elucidating clonal structure in single-cell RNA-sequencing data using mitochondrial variants.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Story, B.
Auteure/Auteur
Velten, L.
Auteure/Auteur
Mönke, G.
Auteure/Auteur
Annan, A.
Auteure/Auteur
Steinmetz, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2631-9268
Statut éditorial
Publié
Date de publication
2024-09
Volume
6
Numéro
3
Première page
lqae095
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Clonal cell population dynamics play a critical role in both disease and development. Due to high mitochondrial mutation rates under both healthy and diseased conditions, mitochondrial genomic variability is a particularly useful resource in facilitating the identification of clonal population structure. Here we present mitoClone2, an all-inclusive R package allowing for the identification of clonal populations through integration of mitochondrial heteroplasmic variants discovered from single-cell sequencing experiments. Our package streamlines the investigation of this phenomenon by providing: built-in compatibility with commonly used tools for the delineation of clonal structure, the ability to directly use multiplexed BAM files as input, annotations for both human and mouse mitochondrial genomes, and helper functions for calling, filtering, clustering, and visualizing variants.
PID Serval
serval:BIB_BCBBBB5D9AA0
DOI
PMID
WOS
Permalien
Open Access
Oui
Date de création
2024-08-19T07:59:08.212Z
Date de création dans IRIS
2025-05-20T23:16:25Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

39131821_BIB_BCBBBB5D9AA0.pdf

Version du manuscrit

published

Licence

https://creativecommons.org/licenses/by/4.0

Taille

1.14 MB

Format

Adobe PDF

PID Serval

serval:BIB_BCBBBB5D9AA0.P001

URN

urn:nbn:ch:serval-BIB_BCBBBB5D9AA02

Somme de contrôle

(MD5):ccd123b222e4085a7ecadbc30c95e1a6