Titre
Lack of association between beta-herpesvirus infection and bronchiolitis obliterans syndrome in lung transplant recipients in the era of antiviral prophylaxis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Manuel, O.
Auteure/Auteur
Kumar, D.
Auteure/Auteur
Moussa, G.
Auteure/Auteur
Chen, M.H.
Auteure/Auteur
Pilewski, J.
Auteure/Auteur
McCurry, K.R.
Auteure/Auteur
Studer, S.M.
Auteure/Auteur
Crespo, M.
Auteure/Auteur
Husain, S.
Auteure/Auteur
Humar, A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1534-6080[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
87
Numéro
5
Première page
719
Dernière page/numéro d’article
725
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
BACKGROUND: Cytomegalovirus (CMV), human herpesvirus-6 and -7 (HHV-6 and -7) are beta-herpesviruses that commonly reactivate and have been proposed to trigger acute rejection and chronic allograft injury. We assessed the contribution of these viruses in the development of bronchiolitis obliterans syndrome (BOS) after lung transplantation. METHODS: Quantitative real-time polymerase chain reaction of bronchoalveolar lavage samples were performed for CMV, HHV-6 and -7 in a prospective cohort of lung transplant recipients. A time-dependent Cox regression analysis was used to correlate the risk of BOS and acute rejection in patients with and without beta-herpesviruses infection. RESULTS: Ninety-three patients were included in the study over a period of 3 years. A total of 581 samples from bronchoalveolar lavage were obtained. Sixty-one patients (65.6%) had at least one positive result for one of the beta-herpesviruses: 48 patients (51.6%) for CMV and 19 patients (20.4%) for both HHV-6 and -7. Median peak viral load was 3419 copies/mL for CMV, 258 copies/mL for HHV-6, and 665 copies/mL for HHV-7. Acute rejection (>or=grade 2) occurred in 46.2% and BOS (>or=stage 1) in 19.4% of the patients. In the Cox regression model the relative risk of acute rejection or BOS was not increased in patients with any beta-herpesviruses reactivation. Acute rejection was the only independently associated risk factor for BOS. CONCLUSIONS: In lung transplant recipients receiving prolonged antiviral prophylaxis, reactivation of beta-herpesviruses within the allograft was common. However, despite high viral loads in many patients, virus replication was not associated with the development of rejection or BOS.
Sujets
PID Serval
serval:BIB_D28E2A39B67A
PMID
Date de création
2009-12-23T16:12:20.092Z
Date de création dans IRIS
2025-05-20T21:16:59Z