Titre
Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Eloranta, J.J.
Auteure/Auteur
Wenger, C.
Auteure/Auteur
Mwinyi, J.
Auteure/Auteur
Hiller, C.
Auteure/Auteur
Gubler, C.
Auteure/Auteur
Vavricka, S.R.
Auteure/Auteur
Fried, M.
Auteure/Auteur
Kullak-Ublick, G.A.
Auteure/Auteur
Contributrices/contributeurs
Ballabeni, P.
Bauerfeind, P.
Beglinger, C.
Begré, S.
Bengoa, J.
Binek, J.
Boller, D.
Borovicka, J.
Braegger, C.
Brun, P.
Bühr, P.
Burnand, B.
Camara, R.
Criblez, D.
de Saussure, P.
Degen, L.
Delarive, J.
Ehmann, T.
Engelmann, M.
El Wafa, A.
Felley, C.
Frei, A.
Frei, R.
Fried, M.
Froehlich, F.
Gallot-Lavallée, S.
Gerlach, T.
Geyer, M.
Girardin, M.
Goetze, O.
Haack, H.
Hediger, S.
Hengstler, P.
Heyland, K.
Janiak, P.
Juillerat, P.
Kessler Brondolo, V.
Knoblauch, C.
Kullak-Ublick, GA.
Manz, M.
Meier, R.
Meyenberger, C.
Michetti, P.
Mottet, C.
Müller, C.
Müllhaupt, B.
Nicolet, T.
Nydegger, A.
Pache, I.
Piccoli, F.
Pilz, J.
Pittet, V.
Rentsch, R.
Rey, JP.
Rihs, S.
Rogler, D.
Rogler, G.
Sagmeister, M.
Sauter, B.
Schaub, N.
Schibli, S.
Schoepfer, A.
Seibold, F.
Spalinger, J.
Stadler, P.
Steuerwald, M.
Straumann, A.
Sulz, M.
Schäppi, M.
Thorens£££Joël£££ J.,
Vader, JP.
Vavricka, S.
Vögtlin, J.
Von Känel, R.
Wachter, G.
Wermuth, J.
Wiesel, P.
Groupes de travail
Swiss IBD Cohort Study Group
Liens vers les personnes
Liens vers les unités
ISSN
1744-6880
Statut éditorial
Publié
Date de publication
2011
Volume
21
Numéro
9
Première page
559
Dernière page/numéro d’article
564
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
OBJECTIVE: Inflammatory bowel diseases (IBDs), Crohn's disease, and ulcerative colitis (UC), are multifactorial disorders, characterized by chronic inflammation of the intestine. A number of genetic components have been proposed to contribute to IBD pathogenesis. In this case-control study, we investigated the association between two common vitamin D-binding protein (DBP) genetic variants and IBD susceptibility. These two single nucleotide polymorphisms (SNPs) in exon 11 of the DBP gene, at codons 416 (GAT>GAG; Asp>Glu) and 420 (ACG>AAG; Thr>Lys), have been previously suggested to play roles in the etiology of other autoimmune diseases.
METHODS: Using TaqMan SNP technology, we have genotyped 884 individuals (636 IBD cases and 248 non-IBD controls) for the two DBP variants.
RESULTS: On statistical analysis, we observed that the DBP 420 variant Lys is less frequent in IBD cases than in non-IBD controls (allele frequencies, P=0.034; homozygous carrier genotype frequencies, P=0.006). This inverse association between the DBP 420 Lys and the disease remained significant, when non-IBD participants were compared with UC (homozygous carrier genotype frequencies, P=0.022) or Crohn's disease (homozygous carrier genotype frequencies, P=0.016) patients separately. Although the DBP position 416 alone was not found to be significantly associated with IBD, the haplotype DBP_2, consisting of 416 Asp and 420 Lys, was more frequent in the non-IBD population, particularly notably when compared with the UC group (Odds ratio, 4.390).
CONCLUSION: Our study adds DBP to the list of potential genes that contribute to the complex genetic etiology of IBD, and further emphasizes the association between vitamin D homeostasis and intestinal inflammation.
METHODS: Using TaqMan SNP technology, we have genotyped 884 individuals (636 IBD cases and 248 non-IBD controls) for the two DBP variants.
RESULTS: On statistical analysis, we observed that the DBP 420 variant Lys is less frequent in IBD cases than in non-IBD controls (allele frequencies, P=0.034; homozygous carrier genotype frequencies, P=0.006). This inverse association between the DBP 420 Lys and the disease remained significant, when non-IBD participants were compared with UC (homozygous carrier genotype frequencies, P=0.022) or Crohn's disease (homozygous carrier genotype frequencies, P=0.016) patients separately. Although the DBP position 416 alone was not found to be significantly associated with IBD, the haplotype DBP_2, consisting of 416 Asp and 420 Lys, was more frequent in the non-IBD population, particularly notably when compared with the UC group (Odds ratio, 4.390).
CONCLUSION: Our study adds DBP to the list of potential genes that contribute to the complex genetic etiology of IBD, and further emphasizes the association between vitamin D homeostasis and intestinal inflammation.
PID Serval
serval:BIB_6ED2E21873F7
PMID
Date de création
2012-03-15T14:54:46.666Z
Date de création dans IRIS
2025-05-20T20:55:52Z