Titre
Dramatic dysbalancing of the Wnt pathway in breast cancers.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Koval, A.
Auteure/Auteur
Katanaev, V.L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2045-2322
Statut éditorial
Publié
Date de publication
2018-05-09
Volume
8
Numéro
1
Première page
7329
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Wnt signaling is important for breast development and remodeling during pregnancy and lactation. Epigenetic modifications change expression levels of components of the Wnt pathway, underlying oncogenic transformation. However, no clear Wnt component increasing expression universally across breast cancer (BC) or its most Wnt-dependent triple-negative BC (TNBC) subgroup has been identified, delaying development of targeted therapies. Here we perform network correlation analysis of expression of >100 Wnt pathway components in hundreds of healthy and cancerous breast tissues. Varying in expression levels among people, Wnt components remarkably coordinate their production; this coordination is dramatically decreased in BC. Clusters with coordinated gene expression exist within the healthy cohort, highlighting Wnt signaling subtypes. Different BC subgroups are identified, characterized by different remaining Wnt signaling signatures, providing the rational for patient stratification for personalizing the therapeutic applications. Key pairwise interactions within the Wnt pathway (some inherited and some established de novo) emerge as targets for future drug discovery against BC.
PID Serval
serval:BIB_6BEF7BCFE5BC
PMID
Open Access
Oui
Date de création
2018-05-17T17:48:06.289Z
Date de création dans IRIS
2025-05-20T20:54:17Z
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Nom
29743726_BIB_6BEF7BCFE5BC.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.47 MB
Format
Adobe PDF
PID Serval
serval:BIB_6BEF7BCFE5BC.P001
URN
urn:nbn:ch:serval-BIB_6BEF7BCFE5BC9
Somme de contrôle
(MD5):da0d8ae6b417f7b41b4ef0e23c5c66e3