Titre
Association between SARS-CoV-2 testing and antibiotic use in Swiss long term care facilities: a retrospective multicentric study
Type
mémoire de master/maîtrise/licence
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
JEANNERET, M.
Auteure/Auteur
Directrices/directeurs
BOILLAT, N.
Directeur⸱rice
Liens vers les personnes
Liens vers les unités
Faculté
Université de Lausanne, Faculté de biologie et médecine
Statut éditorial
Accepté
Date de publication
2024
Nombre de pages
23
Langue
anglais
Résumé
Background
Acute respiratory infections (ARIs) account for 30% of long-term care facilities (LTCFs) infections, frequently leading to antibiotics over-prescription. This study evaluates the impact of SARS-CoV-2 testing on LTCFs antibiotic prescriptions.
Methods
A retrospective study was conducted across 45 LTCFs in Vaud Canton, Switzerland, encompassing 2,427 long-stay beds, from July 2021 to June 2023. Monthly data on SARS-CoV-2 tests and antibiotic prescriptions were collected. Using linear regression adjusted for Swiss viral epidemiology, we assessed the association between (i) SARS-CoV-2 testing, and (ii) positive test results on antibiotic prescriptions.
Results
SARS-CoV-2 testing rates in LTCFs varied, ranging from 0.3% to 16% of residents tested per facility, peaking in January 2022, July 2022, and November 2022. Similar trends were observed for SARS-CoV- 2 test positivity, except for the last testing peak. Antibiotic prescription rates fluctuated moderately, from 3.9% to 7.4% monthly, with minor peaks in December 2021 and April 2022, and a notable peak in January 2023.
No significant association was found between SARS-CoV-2 testing and antibiotic prescriptions (coefficient = -0.03 [95%CI: -0.16; 0.10], p = 0.65). However, positive SARS-CoV-2 tests were negatively associated with prescriptions (coefficient = -0.28 [95%CI: -0.53; -0.03], p = 0.029); a 10% increase in positive tests is associated with a 2.8% reduction in antibiotic prescriptions, with an estimated 3.5 positive tests needed to prevent one prescription.
Conclusion
Overall testing rates showed no impact on antibiotic prescribing, but positive SARS-CoV-2 results correlated with reduced consumption, suggesting more informed prescribing and reducing
unnecessary antibiotics.
Acute respiratory infections (ARIs) account for 30% of long-term care facilities (LTCFs) infections, frequently leading to antibiotics over-prescription. This study evaluates the impact of SARS-CoV-2 testing on LTCFs antibiotic prescriptions.
Methods
A retrospective study was conducted across 45 LTCFs in Vaud Canton, Switzerland, encompassing 2,427 long-stay beds, from July 2021 to June 2023. Monthly data on SARS-CoV-2 tests and antibiotic prescriptions were collected. Using linear regression adjusted for Swiss viral epidemiology, we assessed the association between (i) SARS-CoV-2 testing, and (ii) positive test results on antibiotic prescriptions.
Results
SARS-CoV-2 testing rates in LTCFs varied, ranging from 0.3% to 16% of residents tested per facility, peaking in January 2022, July 2022, and November 2022. Similar trends were observed for SARS-CoV- 2 test positivity, except for the last testing peak. Antibiotic prescription rates fluctuated moderately, from 3.9% to 7.4% monthly, with minor peaks in December 2021 and April 2022, and a notable peak in January 2023.
No significant association was found between SARS-CoV-2 testing and antibiotic prescriptions (coefficient = -0.03 [95%CI: -0.16; 0.10], p = 0.65). However, positive SARS-CoV-2 tests were negatively associated with prescriptions (coefficient = -0.28 [95%CI: -0.53; -0.03], p = 0.029); a 10% increase in positive tests is associated with a 2.8% reduction in antibiotic prescriptions, with an estimated 3.5 positive tests needed to prevent one prescription.
Conclusion
Overall testing rates showed no impact on antibiotic prescribing, but positive SARS-CoV-2 results correlated with reduced consumption, suggesting more informed prescribing and reducing
unnecessary antibiotics.
PID Serval
serval:BIB_DFC0EDEB6692
Date de création
2025-04-24T08:40:50.070Z
Date de création dans IRIS
2025-05-21T06:32:24Z
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Mémoire no 10805 Jeanneret Marc.pdf
Version du manuscrit
imprimatur
Taille
784.05 KB
Format
Adobe PDF
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