Titre

mGlu5-mediated signalling in developing astrocyte and the pathogenesis of autism spectrum disorders.

Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Petrelli, F.
Auteure/Auteur
Bezzi, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1873-6882
Statut éditorial
Publié
Date de publication
2018-02
Volume
48
Première page
139
Dernière page/numéro d’article
145
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Astrocytes, the largest glial population in human and murine brains, are crucial to the regulation of synaptic connectivity. During the first three weeks of postnatal development, immature astrocytes express mGlu5 and expands several fold while undergoing a transition towards their mature phase. Although mGlu5-mediated signalling in astrocyte functions has been extensively studied in the last decades, whether this signalling is implicated in the mechanisms governing their development, as well as the effects of dysregulated astrocytic development on neurodevelopmental disorders, are still unclear. The aim of this review is to examine what is known about the mGlu5-mediated signalling in the developing astrocytes and its possible contribution to the pathophysiology of autism spectrum disorders.
Sujets

Animals

Astrocytes/metabolism...

Autism Spectrum Disor...

Autism Spectrum Disor...

Humans

Receptor, Metabotropi...

Signal Transduction/p...

PID Serval
serval:BIB_0CE5BB9CB8CC
DOI
PMID
WOS
Permalien
Date de création
2018-01-22T08:29:46.729Z
Date de création dans IRIS
2025-05-20T19:05:17Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

29316489Curr Opin_Petrelli_Bezzi (1).pdf

Version du manuscrit

postprint

Licence

https://creativecommons.org/licenses/by-nc-nd/4.0

Taille

500.47 KB

Format

Adobe PDF

PID Serval

serval:BIB_0CE5BB9CB8CC.P001

URN

urn:nbn:ch:serval-BIB_0CE5BB9CB8CC0

Somme de contrôle

(MD5):0cabcdc4ef7d7e3823a9785736e15494