Titre
HIV Transmission Chains Exhibit Greater HLA-B Homogeneity Than Randomly Expected.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Journal of acquired immune deficiency syndromes
Auteur(s)
Nguyen, H.
Auteure/Auteur
Thorball, C.W.
Auteure/Auteur
Fellay, J.
Auteure/Auteur
Böni, J.
Auteure/Auteur
Yerly, S.
Auteure/Auteur
Perreau, M.
Auteure/Auteur
Klimkait, T.
Auteure/Auteur
Kusejko, K.
Auteure/Auteur
Bachmann, N.
Auteure/Auteur
Chaudron, S.E.
Auteure/Auteur
Paioni, P.
Auteure/Auteur
Thurnheer, M.C.
Auteure/Auteur
Battegay, M.
Auteure/Auteur
Cavassini, M.
Auteure/Auteur
Vernazza, P.
Auteure/Auteur
Bernasconi, E.
Auteure/Auteur
Günthard, H.F.
Auteure/Auteur
Kouyos, R.
Auteure/Auteur
Groupes de travail
Swiss HIV Cohort Study
Liens vers les personnes
Liens vers les unités
ISSN
1944-7884
Statut éditorial
Publié
Date de publication
2019-08-15
Volume
81
Numéro
5
Première page
508
Dernière page/numéro d’article
515
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
HIV's capacity to escape immune recognition by human leukocyte antigen (HLA) is a core component of HIV pathogenesis. A better understanding of the distribution of HLA class I in HIV-infected patients would improve our knowledge of pathogenesis in relation to the host HLA type and could better improve therapeutic strategies against HIV.
Three hundred one to 325 transmission pairs and 469-496 clusters were identified for analysis among Swiss HIV Cohort Study (SHCS) participants using HIV pol sequences from the drug resistance database. HLA class I data were compiled at 3 specificity levels: 4-digit, 2-digit alleles, and HLA-B supertype. The analysis tabulated HLA-I homogeneity as 2 measures: the proportion of transmission pairs, which are HLA concordant, and the average percentage of allele matches within all clusters. These measures were compared with the mean value across randomizations with randomly assorted individuals.
We repeated the analysis for different HLA classification levels and separately for HLA-A, -B, and -C. Subanalyses by the risk group were performed for HLA-B. HLA-B showed significantly greater homogeneity in the transmission chains (2-digit clusters: 0.291 vs. 0.251, P value = 0.009; supertype clusters: 0.659 vs. 0.611, P value = 0.002; supertype pairs: 0.655 vs. 0.608, P value = 0.014). Risk group restriction caused the effect to disappear for men-who-have-sex-with-men but not for other risk groups. We also examined if protective HLA alleles B27 and B57 were under- or overrepresented in the transmission chains, although this yielded no significant pattern.
The HLA-B alleles of patients within HIV-1 transmission chains segregate in homogenous clusters/pairs, potentially indicating preferential transmission among HLA-B concordant individuals.
Three hundred one to 325 transmission pairs and 469-496 clusters were identified for analysis among Swiss HIV Cohort Study (SHCS) participants using HIV pol sequences from the drug resistance database. HLA class I data were compiled at 3 specificity levels: 4-digit, 2-digit alleles, and HLA-B supertype. The analysis tabulated HLA-I homogeneity as 2 measures: the proportion of transmission pairs, which are HLA concordant, and the average percentage of allele matches within all clusters. These measures were compared with the mean value across randomizations with randomly assorted individuals.
We repeated the analysis for different HLA classification levels and separately for HLA-A, -B, and -C. Subanalyses by the risk group were performed for HLA-B. HLA-B showed significantly greater homogeneity in the transmission chains (2-digit clusters: 0.291 vs. 0.251, P value = 0.009; supertype clusters: 0.659 vs. 0.611, P value = 0.002; supertype pairs: 0.655 vs. 0.608, P value = 0.014). Risk group restriction caused the effect to disappear for men-who-have-sex-with-men but not for other risk groups. We also examined if protective HLA alleles B27 and B57 were under- or overrepresented in the transmission chains, although this yielded no significant pattern.
The HLA-B alleles of patients within HIV-1 transmission chains segregate in homogenous clusters/pairs, potentially indicating preferential transmission among HLA-B concordant individuals.
PID Serval
serval:BIB_6E0F5A3E41D4
PMID
Date de création
2019-05-25T09:57:56.875Z
Date de création dans IRIS
2025-05-20T23:27:51Z