Titre
Reduction in T gamma delta cell numbers and alteration in subset distribution in systemic lupus erythematosus
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Lunardi, C.
Auteure/Auteur
Marguerie, C.
Auteure/Auteur
Bowness, P.
Auteure/Auteur
Walport, M. J.
Auteure/Auteur
So, A. K.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0009-9104
Statut éditorial
Publié
Date de publication
1991-11
Volume
86
Numéro
2
Première page
203
Dernière page/numéro d’article
6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
We have studied the distribution of T gamma delta cells in the peripheral blood of 35 patients with systemic lupus erythematosus (SLE) and 36 age-matched controls. The monoclonal antibodies A13, BB3 and Ti gamma A, which are specific for the V delta 1, V delta 2 and V delta 9 gene products respectively, were used to define T gamma delta cell subsets. A significantly lower frequency of T gamma delta cells was found in peripheral blood lymphocytes of SLE patients compared with normal subjects (3.2% versus 5.9%). There was a marked reduction in the V delta 2+ subset of T gamma delta cells, which resulted in a reversal of the ratio of V delta 2+/V delta 1+ cells from 4.34 to 0.56. No correlation was found with either clinical or laboratory measures of disease activity. These results suggest that the observed changed in T gamma delta subset distribution are related to the SLE itself, and not secondary to changes in disease activity.
Sujets
PID Serval
serval:BIB_A092E039C813
PMID
Date de création
2008-01-25T07:38:55.577Z
Date de création dans IRIS
2025-05-21T00:44:21Z