Titre
Is the UICC/AJCC pT2 Staging Category for Clear Cell Renal Cell Carcinoma Meaningful?
Type
article
Institution
Externe
Périodique
Auteur(s)
Delahunt, B.
Auteure/Auteur
Dagher, J.
Auteure/Auteur
Egevad, L.
Auteure/Auteur
Yaxley, J.
Auteure/Auteur
Varma, M.
Auteure/Auteur
Samaratunga, H.
Auteure/Auteur
Liens vers les personnes
ISSN
1532-0979
Statut éditorial
Publié
Date de publication
2019-09
Volume
43
Numéro
9
Première page
1249
Dernière page/numéro d’article
1252
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
This study was undertaken to determine the association between extrarenal tumor spread and size in a series of well-sampled clear cell renal cell carcinoma (ccRCC). In a series of 917 cases of ccRCC, 178 were >7 cm in maximum extent. Assessment of tumors >7 cm in size showed 72 (40.4%) to have renal sinus infiltration, the tumor infiltrating perirenal fat in 7 (3.9%) cases, and both in 96 (53.9%) cases. In the remaining 3 (1.7%) cases, no extrarenal extension of the tumor was seen. These 3 cases with organ-confined ccRCC were all cystic tumors. Two showed extensive infarction with associated hemorrhage and the presence of a thick investing pseudocapsule, while the third was a cystic ccRCC arising in the upper pole of the kidney. For the ccRCCs in the series that were ≤7 cm in maximum extent, division of cases according to tumor size and pT staging category showed an increase in the proportion of tumors showing extrarenal spread with increasing size, ranging from 0% for tumors <1 cm in diameter to 84.7% for tumors >6 to 7 cm. The study has shown that for ccRCC, the extrarenal spread of tumor is strongly associated with the size of the primary tumor. The study has also shown that renal sinus invasion and/or perirenal fat infiltration by tumor is commonplace in tumors >7 cm in maximum extent and that tumors of this dimension are rarely organ-confined. These findings provide evidence that the defining features of pT1, pT2, and pT3a staging categories for ccRCC require revision.
PID Serval
serval:BIB_F315ABFA29A5
PMID
Date de création
2022-06-28T06:21:19.146Z
Date de création dans IRIS
2025-05-21T06:46:01Z