Titre
Control of vascular tone by renin and angiotensin in cardiovascular disease
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Brunner, H. R.
Auteure/Auteur
Nussberger, J.
Auteure/Auteur
Waeber, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0195-668X
Statut éditorial
Publié
Date de publication
1993-11
Volume
14 Suppl I
Première page
149
Dernière page/numéro d’article
53
Notes
Journal Article
Review --- Old month value: Nov
Review --- Old month value: Nov
Résumé
The tools which have led to a better understanding of the role of the renin-angiotensin system in determining the tone of peripheral arteries in cardiovascular disease consist of highly specific and sensitive methods to measure the different components of the renin-angiotensin system and in specific probes used to inhibit the renin-angiotensin system at several points of the enzymatic cascade. The therapeutic efficacy of these more and more specific probes undoubtedly provides strong circumstantial evidence that angiotensin II plays an important role in determining peripheral vascular tone. While this has considerably increased our understanding of the regulatory mechanism involved in blood pressure maintenance in normotensive subjects and hypertensive patients, the role of the renin-angiotensin system as an aetiological factor in the development of essential hypertension still remains unclear.
Sujets
PID Serval
serval:BIB_86E03638A51C
PMID
Date de création
2008-03-05T15:39:49.351Z
Date de création dans IRIS
2025-05-21T03:48:26Z