Titre
Die Thromboseresistenz heparinbeschichteter Diffusionsmembranoxygenatoren: eine experimentelle Untersuchung [Thrombosis-resistant heparin-coated diffusion membrane oxygenators: an experimental study].
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Swiss Surgery.
Auteur(s)
Tkebuchava, T.
Auteure/Auteur
von Segesser, L.K.
Auteure/Auteur
Leskosek, B.
Auteure/Auteur
Pei, P.
Auteure/Auteur
Turina, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
Statut éditorial
Publié
Date de publication
1996
Volume
Suppl 1
Première page
36
Dernière page/numéro d’article
40
Langue
allemand
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
In the present study the thromboresistance of heparin-coated diffusion membrane oxygenators (Jostra, M 30) combined with heparin-coated venous reservoirs, tubing sets and arterial filters was investigated in six bovine experiments (70 +/- 5 kg). The perfusion with reduced systemic heparin dose (100 IE/kg) body weight) was performed with activated clotting time over 180 seconds. The perfusion began with a blood flow of 31/min and was maintained during six hours. Clotting studies including blood platelet count, activated clotting time, fibrinogen (factor I), antithrombin III and fibrinopeptid A were performed before the operation and ten minutes, two hours and five and six hours after beginning of bypass. The venous and arterial saturation remained stable during the whole investigation. After ten minutes activated clotting time dropped from 619 +/- 114s to 203 +/- 15s after six hours (p < 0.05). The antithrombin III level changed significantly from 109 +/- 11% to 95 +/- 16%. Factor 1 and fibrinopeptid A changes were not significant: from 1.6 +/- 0.3 g/1 to 1.5 +/- 0.3 g/1, and 3.0 +/- 1.4 ng/mL to 3.5 +/- 1.2 ng/mL, accordingly. There were no mechanical defects and especially no plasma leakage. Slight sediments were found only in areas of stagnant blood flow. The investigated bypass circuit with reduced systemic heparinization seems therefore particularly appropriate for long-term perfusions.
PID Serval
serval:BIB_B33048BBF085
PMID
Date de création
2008-02-14T13:18:26.948Z
Date de création dans IRIS
2025-05-21T00:45:38Z