Titre
Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Conrad, C.
Auteure/Auteur
Boyman, O.
Auteure/Auteur
Tonel, G.
Auteure/Auteur
Tun-Kyi, A.
Auteure/Auteur
Laggner, U.
Auteure/Auteur
de Fougerolles, A.
Auteure/Auteur
Kotelianski, V.
Auteure/Auteur
Gardner, H.
Auteure/Auteur
Nestle, F.O.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1078-8956
Statut éditorial
Publié
Date de publication
2007
Volume
13
Numéro
7
Première page
836
Dernière page/numéro d’article
842
Peer-reviewed
Oui
Langue
anglais
Résumé
Psoriasis is a common T cell-mediated autoimmune inflammatory disease. We show that blocking the interaction of alpha1beta1 integrin (VLA-1) with collagen prevented accumulation of epidermal T cells and immunopathology of psoriasis. Alpha1beta1 integrin, a major collagen-binding surface receptor, was exclusively expressed by epidermal but not dermal T cells. Alpha1beta1-positive T cells showed characteristic surface markers of effector memory cells and contained high levels of interferon-gamma but not interleukin-4. Blockade of alpha1beta1 inhibited migration of T cells into the epidermis in a clinically relevant xenotransplantation model. This was paralleled by a complete inhibition of psoriasis development, comparable to that caused by tumor necrosis factor-alpha blockers. These results define a crucial role for alpha1beta1 in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment focusing on T cell-extracellular matrix interactions.
PID Serval
serval:BIB_D1C84D2FE663
PMID
Date de création
2009-03-31T09:50:25.919Z
Date de création dans IRIS
2025-05-20T21:16:27Z