Titre
A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q - myelodysplastic syndromes.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Voutsadakis, I.A.
Auteure/Auteur
Cairoli, A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1029-2403
Statut éditorial
Publié
Date de publication
2012
Volume
53
Numéro
5
Première page
779
Dernière page/numéro d’article
788
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Abstract The 5q deletion is a chromosomal abnormality that is observed in a subset of myelodysplastic syndromes (MDS). When isolated, this abnormality defines a specific clinical syndrome termed MDS associated with isolated deletion 5q, presenting with macrocytic anemia, normal platelet count or slight thrombocytosis, hypolobated megakaryocytes and fewer than 5% blasts in the bone marrow. MDS with the 5q deletion have a particular sensitivity to treatment with lenalidomide, a thalidomide analog. In this article, molecular changes in 5q- MDS derived from haploinsufficiency of genes encoded from the deleted region in 5q are reviewed, and mechanisms that link these molecular lesions with lenalidomide sensitivity are proposed.
PID Serval
serval:BIB_7F19DEDF7765
PMID
Date de création
2011-10-25T08:17:29.773Z
Date de création dans IRIS
2025-05-20T22:28:58Z