Titre
Preoperative inhibition of angiotensin-converting enzyme improves systemic and renal haemodynamic changes during aortic abdominal surgery.
Type
article
Institution
Externe
Périodique
Auteur(s)
Licker, M.
Auteure/Auteur
Bednarkiewicz, M.
Auteure/Auteur
Neidhart, P.
Auteure/Auteur
Prêtre, R.
Auteure/Auteur
Montessuit, M.
Auteure/Auteur
Favre, H.
Auteure/Auteur
Morel, D.R.
Auteure/Auteur
Liens vers les personnes
ISSN
0007-0912
Statut éditorial
Publié
Date de publication
1996
Volume
76
Numéro
5
Première page
632
Dernière page/numéro d’article
639
Peer-reviewed
Oui
Langue
anglais
Résumé
We studied 22 patients undergoing aortic surgery, allocated randomly to receive, before induction of anaesthesia, a single i.v. dose of enalapril 50 micrograms kg-1 or saline. During infrarenal aortic cross-clamping, we observed similar reductions in oxygen uptake in the two groups, despite greater systemic oxygen delivery in enalapril-treated patients; angiotensin-converting enzyme inhibition prevented the reduction in cardiac output and attenuated the decrease in glomerular filtration. Changes in glomerular filtration secondary to aortic clamping were related positively to changes in renal plasma flow (r = 0.83 (saline group) and r = 0.65 (enalapril group)). Creatinine clearance on the first day after operation was significantly higher in the enalapril compared with the saline group. We conclude that enalapril pretreatment is effective in improving systemic oxygen delivery, renal plasma flow and glomerular filtration during aortic abdominal surgery.
PID Serval
serval:BIB_7756A34E5AD8
PMID
Date de création
2014-12-16T17:05:50.772Z
Date de création dans IRIS
2025-05-21T00:01:47Z