Titre
Pulmonary disposition of vancomycin in critically ill patients.
Type
article
Institution
Externe
Auteur(s)
Georges, H.
Auteure/Auteur
Leroy, O.
Auteure/Auteur
Alfandari, S.
Auteure/Auteur
Guery, B.
Auteure/Auteur
Roussel-Delvallez, M.
Auteure/Auteur
Dhennain, C.
Auteure/Auteur
Beaucaire, G.
Auteure/Auteur
Liens vers les personnes
ISSN
0934-9723
Statut éditorial
Publié
Date de publication
1997-05
Volume
16
Numéro
5
Première page
385
Dernière page/numéro d’article
388
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Vancomycin penetration in epithelium lining fluid was studied in ten mechanically ventilated patients with methicillin-resistant Staphylococcus aureus pneumonia 24 hours after the onset of treatment. Vancomycin was given intravenously at a daily dose of 30 mg/kg. Vancomycin levels were detectable in four patients (range, 1-2.77 micrograms/ml). Concordance between high plasma concentrations (> 20 micrograms/ml) and detectable vancomycin levels in epithelium lining fluid was noted. These results suggest that the pulmonary disposition of vancomycin remains low for most patients 24 h after the onset of treatment compared with the minimum inhibitory concentrations for most gram-positive organisms. One therapeutic goal of vancomycin treatment could be to obtain through plasma levels of 20 micrograms/ml. Further studies are required to determine the clinical relevance of these observations.
Sujets
PID Serval
serval:BIB_322A2DF7686C
PMID
Date de création
2021-04-29T08:59:04.846Z
Date de création dans IRIS
2025-05-20T19:47:50Z