Titre
Radionuclide angiographic determination of regional left ventricular systolic function during rest and exercise in patients with nonischemic cardiomyopathy treated with cardiac resynchronization therapy.
Type
article
Institution
Externe
Périodique
Auteur(s)
Valzania, C.
Auteure/Auteur
Fallani, F.
Auteure/Auteur
Gavaruzzi, G.
Auteure/Auteur
Biffi, M.
Auteure/Auteur
Martignani, C.
Auteure/Auteur
Diemberger, I.
Auteure/Auteur
Bertini, M.
Auteure/Auteur
Domenichini, G.
Auteure/Auteur
Ziacchi, M.
Auteure/Auteur
Gadler, F.
Auteure/Auteur
Eriksson, M.J.
Auteure/Auteur
Braunschweig, F.
Auteure/Auteur
Franchi, R.
Auteure/Auteur
Branzi, A.
Auteure/Auteur
Rapezzi, C.
Auteure/Auteur
Boriani, G.
Auteure/Auteur
Liens vers les personnes
ISSN
1879-1913
Statut éditorial
Publié
Date de publication
2010-08-01
Volume
106
Numéro
3
Première page
389
Dernière page/numéro d’article
394
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Cardiac resynchronization therapy (CRT) can improve global left ventricular (LV) function. However, limited data are available on regional LV contractility at rest and during exercise. The aim of the present study was to prospectively investigate the effects of CRT on regional LV ejection fraction (EF), global LVEF, and dyssynchrony, during rest and exercise, using radionuclide angiography. A total of 32 consecutive patients with heart failure and nonischemic cardiomyopathy underwent technetium-99m radionuclide angiography with bicycle exercise immediately after CRT implantation (during spontaneous rhythm and after CRT activation) and 3 months later. The regional EF was assessed in the interventricular septum and the lateral wall (LW). Intraventricular dyssynchrony was evaluated using Fourier phase analysis. During spontaneous rhythm, the EF was severely depressed in the septum compared to in the LW. CRT improved septal EF at rest and during exercise both at baseline (p <0.001) and after 3 months (p <0.05). The basal LW EF decreased during CRT (p <0.05, both at rest and during exercise). LV dyssynchrony decreased both at baseline and during follow-up, and the global LVEF showed improvement only at 3 months (p <0.001). In conclusion, in patients with nonischemic cardiomyopathy, CRT affects regional LV function by increasing the septal EF and reducing LW contractility, both at rest and during exercise. This was associated with an improvement in global LVEF and dyssynchrony.
PID Serval
serval:BIB_536C06999BEE
PMID
Date de création
2024-03-03T17:07:04.278Z
Date de création dans IRIS
2025-05-20T20:20:19Z