Titre
Plasma monomeric ApoA1 and high-density lipoprotein bound ApoA1 are markedly decreased and associated with low levels of lipophilic antioxidants in sickle cell disease: A potential new pathway for therapy.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Niesor, E.J.
Auteure/Auteur
Perez, A.
Auteure/Auteur
Rezzi, S.
Auteure/Auteur
Hodgson, A.
Auteure/Auteur
Canarelli, S.
Auteure/Auteur
Millet, G.
Auteure/Auteur
Debevec, T.
Auteure/Auteur
Bordat, C.
Auteure/Auteur
Nader, E.
Auteure/Auteur
Connes, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1600-0609
Statut éditorial
Publié
Date de publication
2024-12
Volume
113
Numéro
6
Première page
788
Dernière page/numéro d’article
797
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Patients with sickle cell disease (SCD) exhibit high levels of reactive oxygen species and low plasma levels of lipophilic antioxidants, which may contribute to end-organ damage and disease sequelae. Apolipoprotein A1, the major apolipoprotein of high-density lipoprotein (HDL), is mainly secreted by the intestine and liver in the form of monomeric ApoA1 (mApoA1) present in plasma. Cholesterol and α-tocopherol are delivered to ApoA1 via the ATP-binding cassette transporter, subfamily A, member 1 (ABCA1). We measured cholesterol, mApoA1, ApoA1, and lipophilic antioxidants in the plasma of 17 patients with SCD and 40 healthy volunteers. Mean HDL cholesterol (-C) levels in SCD patients and healthy subjects were 59.3 and 48.1 mg/dL, respectively, and plasma lutein, zeaxanthin, and α-tocopherol were 64.0%, 68.7%, and 9.1% lower, respectively. To compare SCD to healthy subjects with similar HDL-C, we also performed subgroup analyses of healthy subjects with HDL-C above or below the mean. In SCD, the mApoA1 level was 30.4 μg/mL; 80% lower than 141 μg/mL measured in healthy volunteers with similar HDL-C (56.7 mg/dL). The mApoA1 level was also 38.4% greater in the higher versus lower HDL-C subgroups (p = .002). In the higher HDL-C subgroup, lutein and zeaxanthin transported by HDL were 48.9% (p = .01) and 41.9% (p = .02) higher, respectively, whereas α-tocopherol was 31.7% higher (p = .003), compared to the lower HDL-C subgroup. Plasma mApoA1 may be a marker of the capacity of HDL to capture and deliver liposoluble antioxidants, and treatments which raise HDL may benefit patients with high oxidative stress as exemplified by SCD.
Sujets
PID Serval
serval:BIB_F3FB8DD6AFA3
PMID
Open Access
Oui
Date de création
2024-08-26T09:48:45.329Z
Date de création dans IRIS
2025-05-21T05:10:52Z
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Nom
39164995 .pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
1.27 MB
Format
Adobe PDF
PID Serval
serval:BIB_F3FB8DD6AFA3.P001
URN
urn:nbn:ch:serval-BIB_F3FB8DD6AFA31
Somme de contrôle
(MD5):202c2c9c7da184564151d6b5e9fcd1d1