Titre
Macrofollicular variant of follicular thyroid carcinoma: a clinical, cytologic, morphologic, and image analysis study of a unique case.
Type
article
Institution
Externe
Périodique
Auteur(s)
Bongiovanni, M.
Auteure/Auteur
Gremaud, M.
Auteure/Auteur
Moulin, C.S.
Auteure/Auteur
Scheidegger, C.
Auteure/Auteur
Biton, C.
Auteure/Auteur
Clément, S.
Auteure/Auteur
Liens vers les personnes
ISSN
1532-8198
Statut éditorial
Publié
Date de publication
2009
Volume
13
Numéro
2
Première page
101
Dernière page/numéro d’article
105
Langue
anglais
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Résumé
Thyroid lesions composed of large follicles that contain abundant colloid are usually regarded as benign hyperplastic or adenomatous nodules both by fine-needle aspiration cytology and histology. In such cases, the pathologist is less likely to request a complete inclusion of the capsule into paraffin block and to look for vascular and/or capsular invasion, the only criteria that permit the differential diagnosis between a benign nodule and a follicular carcinoma. We report the first case of a follicular thyroid carcinoma composed predominantly (>90%) of macrofollicles with a surface area that was up to 5 times larger than the surface area of normal follicles, as calculated with an image analysis system. Capsular invasion was detected in 2 separate foci. The tumor was classified as a minimally invasive follicular carcinoma, macrofollicular variant. This case is detailed to highlight the potential pitfall that may arise from an incomplete histological analysis of a macrofollicular lesion, with particular attention paid to the differential diagnoses.
PID Serval
serval:BIB_41F8FB62B607
PMID
Date de création
2015-02-05T10:02:26.440Z
Date de création dans IRIS
2025-05-20T17:55:49Z