Titre
Influence of large intakes of trace elements on recovery after major burns
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Berger, M. M.
Auteure/Auteur
Cavadini, C.
Auteure/Auteur
Chiolero, R.
Auteure/Auteur
Guinchard, S.
Auteure/Auteur
Krupp, S.
Auteure/Auteur
Dirren, H.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0899-9007
Statut éditorial
Publié
Date de publication
1994-08
Volume
10
Numéro
4
Première page
327
Dernière page/numéro d’article
34; discussion 352
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article --- Old month value: Jul-Aug
Controlled Clinical Trial
Journal Article --- Old month value: Jul-Aug
Résumé
Because Cu, Se, and Zn are involved in immune and antioxidative defense mechanisms and tissue repair, deficiencies might aggravate complications classically observed with burns. After measuring massive cutaneous trace element losses in 10 burn patients, our aim in this study was to determine whether large intravenous intakes of Cu, Zn, and Se can modify serum trace element levels and recovery after major burns. Ten patients, aged 34 +/- 6 yr (mean +/- SD), admitted to the burns center of a Swiss university hospital with thermal burns on 41 +/- 9% of their body surface were studied prospectively, with trace element balance studies from day 1 (D1) to D7 postinjury. Urine and blood samples were also collected on D10, D15, D20, and D25. The patients were divided into two groups of five and received either standard (group 1, control) or greatly increased (group 2, treatment: 4.5 mg Cu, 190 micrograms Se, and 40 mg Zn/day) trace element intakes. Energy and protein intake and wound treatment were similar in both groups. The treatment group was characterized by improved Cu, Se, and Zn status (increase in serum levels and various protein indicators), a much larger leukocyte increase between D4 and D14 (mainly neutrophils), and shorter hospital stay (45 days) compared with the untreated group (57 days). Grafting requirements were more extensive in group 1. Although severity of injury and wound treatment were similar in the groups, the duration of hospitalization was lower in the treated group. Further studies are required to determine whether this is related to trace element supplementation.
Sujets
PID Serval
serval:BIB_4CAF8E3E423F
PMID
Date de création
2008-01-24T15:52:58.330Z
Date de création dans IRIS
2025-05-20T19:22:37Z