Titre
Rôle potentiel de la noradrénaline dans la dysfonction immune du sepsis [Potential role of norepinephrine in the immune dysfunction associated with sepsis]
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Bauer-Dörries, A.
Co-première auteure/Co-premier auteur
De Cupis, S.
Co-première auteure/Co-premier auteur
Liaudet, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1660-9379
Statut éditorial
Publié
Date de publication
2017-07-12
Volume
13
Numéro
569
Première page
1350
Dernière page/numéro d’article
1353
Peer-reviewed
Oui
Langue
français
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Septic shock may be complicated by a state of immune suppression, with ominous prognosis significance. Although the underlying pathophysiological mechanisms are poorly understood, it is possible that norepinephrine, used to treat circulatory failure during septic shock, plays a significant contributing role. Indeed, besides its hemodynamic effects, norepinephrine exerts multiple immunosuppressive actions, which are primarily mediated by beta-2 adrenergic receptors expressed by immune cells. Furthermore, norepinephrine has the ability to promote the growth of numerous bacteria, and could thereby foster the development of nosocomial infections. Norepinephrine being one of the most prescribed drugs in intensive care medicine, knowledge of these particular immunological effects is essential for the intensive care physicians.
PID Serval
serval:BIB_60A2855BB95E
PMID
Date de création
2017-07-19T09:30:47.274Z
Date de création dans IRIS
2025-05-20T13:47:50Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
RMS_569_1350.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
2.51 MB
Format
Adobe PDF
PID Serval
serval:BIB_60A2855BB95E.P001
URN
urn:nbn:ch:serval-BIB_60A2855BB95E1
Somme de contrôle
(MD5):02436b393ee8ce8d0b3b7e41d897deec