Titre
Human neuropeptide Y potentiates alpha1-adrenergic blood pressure responses in vivo
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Schuerch, L. V.
Auteure/Auteur
Linder, L. M.
Auteure/Auteur
Grouzmann, E.
Auteure/Auteur
Haefeli, W. E.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0363-6135
Statut éditorial
Publié
Date de publication
1998-09
Volume
275
Numéro
3 Pt 2
Première page
H760
Dernière page/numéro d’article
6
Notes
Clinical Trial Controlled Clinical Trial Journal Article Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
Human neuropeptide Y (hNPY) potentiates the postjunctional vasoconstrictor effects of alpha1-adrenoceptor agonists in animals and in human hand veins in vivo. We therefore hypothesized that such an interaction might also occur in the human arterial bed. With the present single-blind cross-over study in 12 healthy volunteers, the effect of subpressor doses of hNPY on the blood pressure response to alpha1-adrenoceptor stimulation was evaluated. Dose-response curves were constructed to intravenously infuse phenylephrine with and without coinfusion with two different doses of hNPY (1.4 and 14.3 pmol . kg-1 . min-1). Blood pressure, heart rate, and forearm blood flow were recorded, and plasma hNPY was determined. During infusion of the higher hNPY dose, which increased hNPY from 24.0 +/- 12.0 to 495.1 +/- 12.6 pmol/l, blood pressure curves were 2.4-fold shifted toward lower phenylephrine dose rates (P < 0.001). Forearm vascular resistance showed a similar trend, whereas the counterregulatory decrease of heart rate was similar in both groups. In contrast, the lower hNPY dose rate producing a fourfold increase in hNPY concentrations did not modify the response to phenylephrine. This in vivo study in humans demonstrates that hNPY induced potentiating effects on alpha1-adrenergic constriction also in the systemic arterial circulation and suggests that circulating hNPY may participate in the control of vascular tone.
Sujets
PID Serval
serval:BIB_6FFA2C9C7C33
PMID
Date de création
2008-01-25T09:55:37.312Z
Date de création dans IRIS
2025-05-20T22:30:24Z