Titre
High genetic diversity of Plasmodium vivax on the north coast of Papua New Guinea.
Type
article
Institution
Externe
Auteur(s)
Arnott, A.
Auteure/Auteur
Barnadas, C.
Auteure/Auteur
Senn, N.
Auteure/Auteur
Siba, P.
Auteure/Auteur
Mueller, I.
Auteure/Auteur
Reeder, J.C.
Auteure/Auteur
Barry, A.E.
Auteure/Auteur
Liens vers les personnes
ISSN
1476-1645
Statut éditorial
Publié
Date de publication
2013
Volume
89
Numéro
1
Première page
188
Dernière page/numéro d’article
194
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Despite having the highest Plasmodium vivax burden in the world, molecular epidemiological data from Papua New Guinea (PNG) for this parasite remain limited. To investigate the molecular epidemiology of P. vivax in PNG, 574 isolates collected from four catchment sites in East Sepik (N = 1) and Madang (N = 3) Provinces were genotyped using the markers MS16 and msp1F3. Genetic diversity and prevalence of P. vivax was determined for all sites. Despite a P. vivax infection prevalence in the East Sepik (15%) catchments less than one-half the prevalence of the Madang catchments (27-35%), genetic diversity was similarly high in all populations (He = 0.77-0.98). High genetic diversity, despite a marked difference in infection prevalence, suggests a large reservoir of diversity in P. vivax populations of PNG. Significant reductions in transmission intensity may, therefore, be required to reduce the diversity of parasite populations in highly endemic countries such as PNG.
Sujets
PID Serval
serval:BIB_4C174713B698
PMID
Open Access
Oui
Date de création
2014-08-08T16:03:20.201Z
Date de création dans IRIS
2025-05-20T17:57:01Z