Titre
Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains.
Type
article
Institution
Externe
Périodique
Auteur(s)
Orci, L.
Auteure/Auteur
Thorens, B.
Auteure/Auteur
Ravazzola, M.
Auteure/Auteur
Lodish, H.F.
Auteure/Auteur
Liens vers les personnes
ISSN
0036-8075[print], 0036-8075[linking]
Statut éditorial
Publié
Date de publication
1989-07
Volume
245
Numéro
4915
Première page
295
Dernière page/numéro d’article
297
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Résumé
Immunocytochemical techniques revealed that the "liver-type" glucose transporter is present in the insulin-producing beta cells of rat pancreatic islets but not in other islet endocrine cells. Ultrastructural analysis of the transporter by the protein A-gold technique showed that it is restricted to certain domains of the plasma membrane, its density being sixfold higher in microvilli facing adjacent endocrine cells than in the flat regions of the plasma membrane. These results support a possible role for this glucose transporter in glucose sensing by beta cells and provide evidence that these cells are polarized.
PID Serval
serval:BIB_34D8218A280B
PMID
Date de création
2008-01-24T12:41:11.205Z
Date de création dans IRIS
2025-05-20T13:20:13Z