Titre
Role of peroxynitrite in the redox regulation of cell signal transduction pathways.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Liaudet, Lucas
Auteure/Auteur
Vassalli, Giuseppe
Auteure/Auteur
Pacher, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1093-4715[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
14
Première page
4809
Dernière page/numéro d’article
4814
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review Publication Status: epublish
Résumé
Peroxynitrite is a potent oxidant and nitrating species formed from the reaction between the free radicals nitric oxide and superoxide. An excessive formation of peroxynitrite represents an important mechanism contributing to cell death and dysfunction in multiple cardiovascular pathologies, such as myocardial infarction, heart failure and atherosclerosis. Whereas initial works focused on direct oxidative biomolecular damage as the main route of peroxynitrite toxicity, more recent evidence, mainly obtained in vitro, indicates that peroxynitrite also behaves as a potent modulator of various cell signal transduction pathways. Due to its ability to nitrate tyrosine residues, peroxynitrite affects cellular processes dependent on tyrosine phosphorylation. Peroxynitrite also exerts complex effects on the activity of various kinases and phosphatases, resulting in the up- or downregulation of signalling cascades, in a concentration- and cell-dependent manner. Such roles of peroxynitrite in the redox regulation of key signalling pathways for cardiovascular homeostasis, including protein kinase B and C, the MAP kinases, Nuclear Factor Kappa B, as well as signalling dependent on insulin and the sympatho-adrenergic system are presented in detail in this review.
PID Serval
serval:BIB_9EDAAC023D45
PMID
Date de création
2009-12-29T09:19:10.952Z
Date de création dans IRIS
2025-05-21T03:52:13Z
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Nom
BIB_9EDAAC023D45.P001.pdf
Version du manuscrit
preprint
Taille
1.41 MB
Format
Adobe PDF
PID Serval
serval:BIB_9EDAAC023D45.P001
URN
urn:nbn:ch:serval-BIB_9EDAAC023D456
Somme de contrôle
(MD5):336d1efaea99e4a7aca5de1aeb8c1b72