Titre
Association between C-reactive protein and adiposity in women.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Bochud, M.
Auteure/Auteur
Marquant, F.
Auteure/Auteur
Marques-Vidal, P.M.
Auteure/Auteur
Vollenweider, P.
Auteure/Auteur
Beckmann, J.S.
Auteure/Auteur
Mooser, V.
Auteure/Auteur
Paccaud, F.
Auteure/Auteur
Rousson, V.
Auteure/Auteur
ISSN
0021-972X
Statut éditorial
Publié
Date de publication
2009
Volume
94
Numéro
10
Première page
3969
Dernière page/numéro d’article
3977
Peer-reviewed
Oui
Langue
anglais
Résumé
Context: The link between C-reactive protein (CRP) and adiposity deserves to be further explored considering the controversial diabetogenic role of CRP. Objective: We explored the potential causal role of CRP on measures of adiposity. Design: We used a Mendelian randomization approach with the CRP and LEPR genes as instrumental variables in a cross-sectional Caucasian population-based study comprising 2526 men and 2836 women. Adiposity was measured using body mass index (BMI), fat and lean mass estimated by bioelectrical impedance, and waist circumference. Results: Log-transformed CRP explained by the rs7553007 SNP tagging the CRP gene was significantly associated with BMI (regression coefficient: 1.22 [0.18;2.25], P=0.02) and fat mass (2.67 [0.65;4.68], P=0.01), but not with lean mass in women, whereas no association was found in men. Log-transformed CRP explained by the rs1805096 LEPR SNP was also positively associated, although not significantly, with BMI or fat mass. The combined CRP-LEPR instrument explained 2.24% and 0.77% of CRP variance in women and in men, respectively. Log-transformed CRP explained by this combined instrument was significantly associated with BMI (0.98 [0.32;1.63], P=0.004), fat mass (2.07 [0.79;3.34], P=0.001) and waist (2.09 [0.39;3.78], P=0.01) in women, but not in men. Conclusion: Our data suggest that CRP is causally and positively related to BMI in women, and that this is mainly due to fat mass. Results on the combined CRP-LEPR instrument suggest that leptin may play a role in the causal association between CRP and adiposity in women. Results in men were not significant.
PID Serval
serval:BIB_A69EB62E1EDA
PMID
Open Access
Oui
Date de création
2009-07-17T08:34:00.341Z
Date de création dans IRIS
2025-05-20T23:47:54Z
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Nom
BIB_A69EB62E1EDA.P001.pdf
Version du manuscrit
preprint
Taille
129.77 KB
Format
Adobe PDF
PID Serval
serval:BIB_A69EB62E1EDA.P001
Somme de contrôle
(MD5):0792bf4cfe510ea546c221ca86b525b3