Titre
In Vitro Evaluation and Clinical Effects of a Regenerative Complex with Non-Cross-Linked Hyaluronic Acid and a High-Molecular-Weight Polynucleotide for Periorbital Treatment.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Abuyousif, H.S.
Auteure/Auteur
Porcello, A.
Auteure/Auteur
Cerrano, M.
Auteure/Auteur
Marques, C.
Auteure/Auteur
Scaletta, C.
Auteure/Auteur
Lourenço, K.
Auteure/Auteur
Abdel-Sayed, P.
Auteure/Auteur
Chemali, M.
Auteure/Auteur
Raffoul, W.
Auteure/Auteur
Hirt-Burri, N.
Auteure/Auteur
Applegate, L.A.
Auteure/Auteur
Laurent, A.E.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2073-4360
Statut éditorial
Publié
Date de publication
2025-02-27
Volume
17
Numéro
5
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Skin aging is a complex and multifactorial process influenced by both intrinsic and extrinsic factors. The periorbital area of the face is particularly susceptible to premature aging signs due to its delicate skin structure, and is a major concern for many individuals. While hyaluronic acid (HA)-based dermal filler products are commonly used for periorbital rejuvenation, novel approaches to effectively locally address the visible signs of aging are available. This study aimed to investigate Innovyal Regenerative Action (IRA), an injectable polynucleotide-HA (PN-HA) regenerative complex designed for periocular prejuvenation. Firstly, PN-HA was compared to other commercially available HA-based dermbooster products (Profhilo <sup>®</sup> , Suisselle Cellbooster <sup>®</sup> Glow, and NCTF <sup>®</sup> 135 HA) in terms of rheological properties, in vitro antioxidant capacity, and total collagen production stimulation in human fibroblasts. Secondly, the clinical effects of the IRA PN-HA complex were evaluated in two case reports (monotherapy for periorbital prejuvenation). It was shown that the PN-HA complex outperformed its comparators in terms of relative rheological behavior (biophysical attributes normalized to polymer contents), intrinsic antioxidant activity (CUPRAC, FRAP, and ORAC assays), as well as total collagen level induction (72-h in vitro dermal fibroblast induction model). Generally, the results of this study provided mechanistic and preliminary clinical insights into the potential benefits of the IRA PN-HA complex for periocular cutaneous treatment. Overall, it was underscored that combining the structural support and regenerative properties of PN with the hydrating and volumizing effects of HA bares tangible potential for multifactorial skin quality enhancement and for periocular prejuvenation in particular.
PID Serval
serval:BIB_0047D0845F23
PMID
Open Access
Oui
Date de création
2025-03-21T12:31:23.755Z
Date de création dans IRIS
2025-05-20T13:39:12Z