Titre
The required beta cell research for improving treatment of type 2 diabetes.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Thorens, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1365-2796
Statut éditorial
Publié
Date de publication
2013
Volume
274
Numéro
3
Première page
203
Dernière page/numéro d’article
214
Langue
anglais
Résumé
In healthy individuals, insulin resistance is associated with physiological conditions such as pregnancy or body weight gain and triggers an increase in beta cell number and insulin secretion capacity to preserve normoglycaemia. Failure of this beta cell compensation capacity is a fundamental cause of diabetic hyperglycaemia. Incomplete understanding of the molecular mechanisms controlling the plasticity of adult beta cells mechanisms and how these cells fail during the pathogenesis of diabetes strongly limits the ability to develop new beta cell-specific therapies. Here, current knowledge of the signalling pathways controlling beta cell plasticity is reviewed, and possible directions for future research are discussed.
PID Serval
serval:BIB_4A66DC9B3E91
PMID
Open Access
Oui
Date de création
2013-09-05T11:58:50.479Z
Date de création dans IRIS
2025-05-20T17:56:08Z