Titre
Changing Trends in International Versus Domestic HCV Transmission in HIV-Positive Men Who Have Sex With Men: A Perspective for the Direct-Acting Antiviral Scale-Up Era.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Salazar-Vizcaya, L.
Auteure/Auteur
Kouyos, R.D.
Auteure/Auteur
Metzner, K.J.
Auteure/Auteur
Caraballo Cortes, K.
Auteure/Auteur
Böni, J.
Auteure/Auteur
Shah, C.
Auteure/Auteur
Fehr, J.
Auteure/Auteur
Braun, D.L.
Auteure/Auteur
Bernasconi, E.
Auteure/Auteur
Mbunkah, H.A.
Auteure/Auteur
Hoffmann, M.
Auteure/Auteur
Labhardt, N.
Auteure/Auteur
Cavassini, M.
Auteure/Auteur
Rougemont, M.
Auteure/Auteur
Günthard, H.F.
Auteure/Auteur
Keiser, O.
Auteure/Auteur
Rauch, A.
Auteure/Auteur
Groupes de travail
Swiss HIV Cohort Study
Liens vers les personnes
Liens vers les unités
ISSN
1537-6613
Statut éditorial
Publié
Date de publication
2019-06-05
Volume
220
Numéro
1
Première page
91
Dernière page/numéro d’article
99
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Scale-up of direct-acting antiviral therapy is expected to abate hepatitis C virus (HCV) incidence among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). International transmission could influence this process. We classified HCV infections in HIV-positive MSM as either domestically or internationally acquired, and estimated how this classification changed over time.
HCV subtype 1a (the most frequent subtype among MSM) genomes from 99 persons enrolled in the Swiss HIV Cohort Study and diagnosed with replicating HCV infections, were sequenced. Sixty-six of these sequences were from MSM. We inferred maximum-likelihood phylogenetic trees and time trees containing a fragment of the NS5B region of these and 374 circulating strains. We inferred transmission clusters from these trees and used the country composition of such clusters to attribute infections to domestic or international transmission.
Of HCV transmissions, 50% to 80% were classified as domestic depending on the classification criterion. Between 2000 and 2007, the fraction attributable to domestic transmission was 54% (range 0-75%). It increased to 85% (range 67%-100%) between 2008 and 2016.
International and domestic transmission have played major roles in this epidemic. While international transmission persists, local transmission has established as the main source of infections.
HCV subtype 1a (the most frequent subtype among MSM) genomes from 99 persons enrolled in the Swiss HIV Cohort Study and diagnosed with replicating HCV infections, were sequenced. Sixty-six of these sequences were from MSM. We inferred maximum-likelihood phylogenetic trees and time trees containing a fragment of the NS5B region of these and 374 circulating strains. We inferred transmission clusters from these trees and used the country composition of such clusters to attribute infections to domestic or international transmission.
Of HCV transmissions, 50% to 80% were classified as domestic depending on the classification criterion. Between 2000 and 2007, the fraction attributable to domestic transmission was 54% (range 0-75%). It increased to 85% (range 67%-100%) between 2008 and 2016.
International and domestic transmission have played major roles in this epidemic. While international transmission persists, local transmission has established as the main source of infections.
Sujets
PID Serval
serval:BIB_DB771CDF18E0
PMID
Open Access
Oui
Date de création
2019-03-25T08:42:40.437Z
Date de création dans IRIS
2025-05-21T05:30:02Z
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Nom
30759225_BIB_DB771CDF18E0.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by-nc-nd/4.0
Taille
3.17 MB
Format
Adobe PDF
PID Serval
serval:BIB_DB771CDF18E0.P001
URN
urn:nbn:ch:serval-BIB_DB771CDF18E06
Somme de contrôle
(MD5):33152d04c0e106c1e2dfa1c5f42e3f98