Titre
Fluoreszenzdiagnostik bei Patienten mit nicht muskelinvasivem Harnblasenkarzinom: Ergebnisse einer Metaanalyse [Fluorescence diagnosis in patients with non-muscle invasive bladder cancer: results of a metaanalysis]
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Aktuelle Urologie
Auteur(s)
Kausch, I.
Auteure/Auteur
Sommerauer, M.
Auteure/Auteur
Montorsi, F.
Auteure/Auteur
Stenzl, A.
Auteure/Auteur
Jacqmin, D.
Auteure/Auteur
Jichlinski, P.
Auteure/Auteur
Jocham, D.
Auteure/Auteur
Ziegler, A.
Auteure/Auteur
Vonthein, R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1438-8820[electronic], 0001-7868[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
41
Numéro
3
Première page
171
Dernière page/numéro d’article
177
Langue
allemand
Résumé
Purpose: Heterogeneous results of single studies with photodynamic diagnosis (PDD) in bladder cancer have been reported. A metaanalysis of prospective studies has now been performed.
Material and Methods: The effect of PDD in addition to WLC on a) the diagnosis and b) the therapeutic outcome of primary or recurrent non-muscle invasive bladder cancer (NMIBC) investigated by cystoscopy or transurethral resection was analysed. An electronic database search was performed. Trials were included if they prospectively compared WLC with PDD in bladder cancer. Primary endpoints were additional detection rate, residual tumour at second resection and recurrence-free survival.
Results: Significantly more tumour-positive patients were detected with PDD in all patients with non-muscle invasive tumours (= 20%) [95% confidence interval (CI): 8 to 35%] and in CIS patients (= 39%) (CI: 23 to 57%). Residual tumour was significantly less often found after PDD (odds ratio 0.28, CI: 0.15 to 0.52, p<0.0001). Recurrence-free survival was significantly higher at 12 and 24months in the PDD groups than in WLC only groups.
Conclusions: More bladder tumour-positive patients are detected by PDD. Best results were found in CIS patients. Diagnosis with PDD results in a more complete resection and a longer recurrence-free survival.
Material and Methods: The effect of PDD in addition to WLC on a) the diagnosis and b) the therapeutic outcome of primary or recurrent non-muscle invasive bladder cancer (NMIBC) investigated by cystoscopy or transurethral resection was analysed. An electronic database search was performed. Trials were included if they prospectively compared WLC with PDD in bladder cancer. Primary endpoints were additional detection rate, residual tumour at second resection and recurrence-free survival.
Results: Significantly more tumour-positive patients were detected with PDD in all patients with non-muscle invasive tumours (= 20%) [95% confidence interval (CI): 8 to 35%] and in CIS patients (= 39%) (CI: 23 to 57%). Residual tumour was significantly less often found after PDD (odds ratio 0.28, CI: 0.15 to 0.52, p<0.0001). Recurrence-free survival was significantly higher at 12 and 24months in the PDD groups than in WLC only groups.
Conclusions: More bladder tumour-positive patients are detected by PDD. Best results were found in CIS patients. Diagnosis with PDD results in a more complete resection and a longer recurrence-free survival.
Sujets
PID Serval
serval:BIB_8069F92E5260
PMID
Date de création
2010-07-06T09:26:35.536Z
Date de création dans IRIS
2025-05-21T04:40:14Z