Titre
The first uterine pass effect
Type
synthèse (review)
Institution
Externe
Périodique
Auteur(s)
De Ziegler, D.
Auteure/Auteur
Bulletti, C.
Auteure/Auteur
De Monstier, B.
Auteure/Auteur
Jaaskelainen, A. S.
Auteure/Auteur
Liens vers les personnes
ISSN
0077-8923
Statut éditorial
Publié
Date de publication
1997-09
Volume
828
Première page
291
Dernière page/numéro d’article
9
Peer-reviewed
Oui
Notes
Journal Article
Review --- Old month value: Sep 26
Review --- Old month value: Sep 26
Résumé
The endometrial effects of vaginal progesterone have been found to be unexpectedly reliable. This has led us to suspect that a local direct vagina-to-uterus transport or first uterine pass effect was the basis of the uterine targeting of vaginal progesterone. After vaginal administration of progesterone, uterine tissue concentration has been found to exceed by more than 10-fold the levels achieved by systemic administration, despite plasma levels in the latter case that were more than seven times higher. Similar differences in systemic-to-uterine tissue level ratios have been observed between oral and vaginal administration of danazol. Originally seen as a pharmacological advantage permitting the uterine targeting of vaginally administered substances, it is possible that the first uterine pass effect plays a physiological role in the control of uterine contractile activity through the prostaglandins contained in the semen.
Sujets
PID Serval
serval:BIB_DBDF645084F8
PMID
Date de création
2008-02-28T10:37:00.312Z
Date de création dans IRIS
2025-05-20T22:51:52Z