Titre
Comparison of renin and converting enzyme inhibition in sodium-deficient dogs
Type
article
Institution
Externe
Périodique
Auteur(s)
Blaine, E. H.
Auteure/Auteur
Nelson, B. J.
Auteure/Auteur
Seymour, A. A.
Auteure/Auteur
Schorn, T. W.
Auteure/Auteur
Sweet, C. S.
Auteure/Auteur
Slater, E. E.
Auteure/Auteur
Nussberger, J.
Auteure/Auteur
Boger, J.
Auteure/Auteur
Liens vers les personnes
ISSN
0194-911X
Statut éditorial
Publié
Date de publication
1985-06
Volume
7
Numéro
3 Pt 2
Première page
I66
Dernière page/numéro d’article
71
Notes
Comparative Study
Journal Article --- Old month value: May-Jun
Journal Article --- Old month value: May-Jun
Résumé
While renin is a highly specific protease, converting enzyme has at least two principal substrates, angiotensin I and bradykinin. Changes in the rate of formation of angiotensin II or degradation of bradykinin can influence the hypotensive action of angiotensin converting enzyme inhibitors. The present study was designed to determine if there were differences in the maximal blood pressure reduction in Na-deficient dogs after angiotensin converting enzyme or renin inhibitor treatment. Five conscious dogs received 0.1, 0.5, and 1.0 mg/kg of i.v. enalaprilat, a potent angiotensin converting enzyme inhibitor, which reduced blood pressure to 75 +/- 4, 71 +/- 5, and 71 +/- 5 mm Hg. Plasma immunoreactive angiotensin II levels were reduced in a dose-related fashion to 35% of control level at the highest dose. Infusion of a maximally effective dose of a statine-containing renin inhibitor (SCRIP) with the high dose of enalaprilat produced no further fall in blood pressure (68 +/- 7 mm Hg), but immunoreactive angiotensin II levels fell to essentially zero in four of five dogs. The order of drug administration was reversed in another experiment in a group of nine dogs in which SCRIP reduced plasma immunoreactive angiotensin II to 25% of control at 0.04 mg/kg/minute (n = 5), with reduction to near zero levels at higher doses. Maximal blood pressure reduction was achieved at 0.32 to 0.64 mg/kg/minute (76 +/- 4 mm Hg); 1 mg/kg of enalaprilat lowered blood pressure an additional 11 +/- 2 mm Hg (p less than 0.01) while not further decreasing immunoreactive angiotensin II levels.(ABSTRACT TRUNCATED AT 250 WORDS)
Sujets
PID Serval
serval:BIB_22291FDD17FC
PMID
Date de création
2008-03-05T15:41:23.494Z
Date de création dans IRIS
2025-05-20T13:21:07Z