Titre
Neurochemical changes within human early blind occipital cortex.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Weaver, K.E.
Auteure/Auteur
Richards, T.L.
Auteure/Auteur
Saenz, M.
Auteure/Auteur
Petropoulos, H.
Auteure/Auteur
Fine, I.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1873-7544
Statut éditorial
Publié
Date de publication
2013-11-12
Volume
252
Première page
222
Dernière page/numéro d’article
233
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Publication Status: ppublish
Résumé
Early blindness results in occipital cortex neurons responding to a wide range of auditory and tactile stimuli. These changes in tuning properties are accompanied by an extensive reorganization of the occipital cortex that includes alterations in anatomical structure, neurochemical and metabolic pathways. Although it has been established in animal models that neurochemical pathways are heavily affected by early visual deprivation, the effects of blindness on these pathways in humans is still not well characterized. Here, using (1)H magnetic resonance spectroscopy in nine early blind and normally sighted subjects, we find that early blindness is associated with higher levels of creatine, choline and myo-Inositol and indications of lower levels of GABA within the occipital cortex. These results suggest that the cross-modal responses associated with early blindness may, at least in part, be driven by changes within occipital biochemical pathways.
Sujets
PID Serval
serval:BIB_9CA0341D1DEF
PMID
Date de création
2013-11-21T16:58:53.075Z
Date de création dans IRIS
2025-05-20T21:37:18Z