Titre
Structure of replicating herpes simplex virus DNA
Type
article
Institution
Externe
Périodique
Auteur(s)
Jongeneel, C. V.
Auteure/Auteur
Bachenheimer, S. L.
Auteure/Auteur
Liens vers les personnes
ISSN
0022-538X
Statut éditorial
Publié
Date de publication
1981-08
Volume
39
Numéro
2
Première page
656
Dernière page/numéro d’article
60
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Résumé
We have investigated the molecular anatomy of the herpes simplex virus replicative intermediates by cleavage with the restriction endonuclease BglII. We find that in populations of multiply infected cells, pulse-labeled replicating herpes simplex virus DNA contains at least two and probably all four sequence isomers. Also, it contains no detectable termini. In pulse-chase experiments, we show that endless replicative intermediates are the precursors to virion DNA and that maturation is a relatively slow process. The results are discussed in terms of their significance to possible models of herpes simplex virus DNA replication.
Sujets
PID Serval
serval:BIB_153588F7BBC5
PMID
Date de création
2008-01-24T14:40:01.033Z
Date de création dans IRIS
2025-05-20T20:01:15Z