Titre
The spectrum of opportunistic diseases complicating sarcoidosis.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Jamilloux, Y.
Auteure/Auteur
Valeyre, D.
Auteure/Auteur
Lortholary, O.
Auteure/Auteur
Bernard, C.
Auteure/Auteur
Kerever, S.
Auteure/Auteur
Lelievre, L.
Auteure/Auteur
Neel, A.
Auteure/Auteur
Broussolle, C.
Auteure/Auteur
Seve, P.
Auteure/Auteur
Liens vers les unités
ISSN
1873-0183
Statut éditorial
Publié
Date de publication
2014
Volume
14
Numéro
1
Première page
64
Dernière page/numéro d’article
74
Langue
anglais
Résumé
Sarcoidosis is an inflammatory disease marked by a paradoxical immune status. The anergic state, which results from various immune defects, contrasts with the inflammatory formation of granulomas. Sarcoidosis patients may be at risk for opportunistic infections (OIs) and a substantial number of cases have been reported, even in untreated sarcoidosis. It is not clear how OIs in patients with sarcoidosis are different from other groups at risk. In this review, we discuss the most common OIs: mycobacterial infection (including tuberculosis), cryptococcosis, progressive multifocal leukoencephalopathy, and aspergillosis. Unlike peripheral lymphocytopenia, corticosteroids are a major risk factor for OIs but the occurrence of Ols in untreated patients suggests more complex predisposing mechanisms. Opportunistic infections presenting with extrapulmonary features are often misdiagnosed as new localizations of sarcoidosis. Aspergillomas mostly develop on fibrocystic lungs. Overall, physicians should be aware of the possible occurrence of OIs during sarcoidosis, even in untreated patients.
PID Serval
serval:BIB_A8FE4384EF7C
PMID
Date de création
2015-01-02T08:27:37.276Z
Date de création dans IRIS
2025-05-20T23:14:23Z