Titre
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Vozenin, M.C.
Auteure/Auteur
De Fornel, P.
Auteure/Auteur
Petersson, K.
Auteure/Auteur
Favaudon, V.
Auteure/Auteur
Jaccard, M.
Auteure/Auteur
Germond, J.F.
Auteure/Auteur
Petit, B.
Auteure/Auteur
Burki, M.
Auteure/Auteur
Ferrand, G.
Auteure/Auteur
Patin, D.
Auteure/Auteur
Bouchaab, H.
Auteure/Auteur
Ozsahin, M.
Auteure/Auteur
Bochud, F.
Auteure/Auteur
Bailat, C.
Auteure/Auteur
Devauchelle, P.
Auteure/Auteur
Bourhis, J.
Auteure/Auteur
Liens vers les unités
ISSN
1078-0432
Statut éditorial
Publié
Date de publication
2019-01-01
Volume
25
Numéro
1
Première page
35
Dernière page/numéro d’article
42
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this effect could also occur in higher mammals.
Pig skin was used to investigate a potential difference in toxicity between irradiation delivered at an ultrahigh dose rate called "FLASH-RT" and irradiation delivered at a conventional dose rate called "Conv-RT." A clinical, phase I, single-dose escalation trial (25-41 Gy) was performed in 6 cat patients with locally advanced T2/T3N0M0 squamous cell carcinoma of the nasal planum to determine the maximal tolerated dose and progression-free survival (PFS) of single-dose FLASH-RT.
Using, respectively, depilation and fibronecrosis as acute and late endpoints, a protective effect of FLASH-RT was observed (≥20% dose-equivalent difference vs. Conv-RT). Three cats experienced no acute toxicity, whereas 3 exhibited moderate/mild transient mucositis, and all cats had depilation. With a median follow-up of 13.5 months, the PFS at 16 months was 84%.
Our results confirmed the potential advantage of FLASH-RT and provide a strong rationale for further evaluating FLASH-RT in human patients.See related commentary by Harrington, p. 3.
Pig skin was used to investigate a potential difference in toxicity between irradiation delivered at an ultrahigh dose rate called "FLASH-RT" and irradiation delivered at a conventional dose rate called "Conv-RT." A clinical, phase I, single-dose escalation trial (25-41 Gy) was performed in 6 cat patients with locally advanced T2/T3N0M0 squamous cell carcinoma of the nasal planum to determine the maximal tolerated dose and progression-free survival (PFS) of single-dose FLASH-RT.
Using, respectively, depilation and fibronecrosis as acute and late endpoints, a protective effect of FLASH-RT was observed (≥20% dose-equivalent difference vs. Conv-RT). Three cats experienced no acute toxicity, whereas 3 exhibited moderate/mild transient mucositis, and all cats had depilation. With a median follow-up of 13.5 months, the PFS at 16 months was 84%.
Our results confirmed the potential advantage of FLASH-RT and provide a strong rationale for further evaluating FLASH-RT in human patients.See related commentary by Harrington, p. 3.
PID Serval
serval:BIB_CD8C3C9FC9A2
PMID
Open Access
Oui
Date de création
2018-06-25T15:22:10.012Z
Date de création dans IRIS
2025-05-21T03:37:22Z