Titre
A mathematical model of pathogenesis in idiopathic parkinsonism
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Schulzer, M.
Auteure/Auteur
Lee, C. S.
Auteure/Auteur
Mak, E. K.
Auteure/Auteur
Vingerhoets, F. J.
Auteure/Auteur
Calne, D. B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0006-8950
Statut éditorial
Publié
Date de publication
1994-06
Volume
117 ( Pt 3)
Première page
509
Dernière page/numéro d’article
16
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
We used our observations relating clinical deficits in idiopathic parkinsonism (IP) to age and to disease duration (Lee et al, Brain 1994; 117: 501-7), to develop a mathematical model of the temporal profile of neurodegeneration in IP. We also examined other sets of relevant published observations and applied three additional assumptions which permitted the formulation of this model. Our model indicates that accelerating or decelerating processes should be excluded as the driving forces behind neuronal death in IP. Mechanisms in accord with the model include: (i) an event that kills some neurons and damages others in such a way that their life expectation is reduced; or (ii) an event that starts a process which is continuously killing healthy neurons at a constant rate. The model enables us to extrapolate back to estimate when the causal event occurred. It also explains why IP proceeds more rapidly in older patients. The model has potential relevance to other neurodegenerative disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis.
Sujets
PID Serval
serval:BIB_DA41931898E4
PMID
Date de création
2008-01-25T11:49:13.017Z
Date de création dans IRIS
2025-05-21T00:58:10Z