Titre
CD4+ T cell responses to SSX-4 in melanoma patients
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Ayyoub, M.
Auteure/Auteur
Merlo, A.
Auteure/Auteur
Hesdorffer, C. S.
Auteure/Auteur
Rimoldi, D.
Auteure/Auteur
Speiser, D.
Auteure/Auteur
Cerottini, J. C.
Auteure/Auteur
Chen, Y. T.
Auteure/Auteur
Old, L. J.
Auteure/Auteur
Stevanovic, S.
Auteure/Auteur
Valmori, D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0022-1767
Statut éditorial
Publié
Date de publication
2005-04
Volume
174
Numéro
8
Première page
5092
Dernière page/numéro d’article
9
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Apr 15
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Apr 15
Résumé
Genes of the synovial sarcoma X breakpoint (SSX) family are expressed in different human tumors, including melanomas, but not in adult somatic tissues. Because of their specific expression at the tumor site, SSX-encoded Ags are potential targets for anticancer immunotherapy. In this study, we have analyzed CD4+ T cell responses directed against the Ag encoded by SSX-4. Upon in vitro stimulation of PBMC from four melanoma patients bearing Ag-expressing tumors with a pool of long peptides spanning the protein sequence, we detected and isolated SSX-4-specific CD4+ T cells recognizing several distinct antigenic sequences, mostly restricted by frequently expressed HLA class II alleles. The majority of the identified sequences were located within the Kruppel-associated box domain in the N-terminal region of the protein, indicating a high potential immunogenicity of this region. Together our data document the existence of CD4+ T cells specific for multiple SSX-4 derived sequences in circulating lymphocytes from melanoma patients and encourage further studies to assess the impact of SSX-4-specific T cell responses on disease evolution in cancer patients.
Sujets
PID Serval
serval:BIB_62F457F17305
PMID
Date de création
2008-01-28T10:13:44.803Z
Date de création dans IRIS
2025-05-20T22:20:05Z