Titre
Acetylation of maprotiline and desmethylmaprotiline in depressive patients phenotyped with sulfamidine, debrisoquine, and mephenytoin.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Arzneimittel-Forschung
Auteur(s)
Baumann, P.
Auteure/Auteur
Bosshart, P.
Auteure/Auteur
Gabris, G.
Auteure/Auteur
Gastpar, M.
Auteure/Auteur
Koeb, L.
Auteure/Auteur
Woggon, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0004-4172
Statut éditorial
Publié
Date de publication
1988-02
Volume
38
Numéro
2
Première page
292
Dernière page/numéro d’article
296
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
A gas chromatographic/mass spectrometric method (using either electron impact or chemical ionisation with methane or ammonia) is described for the quantitative analysis of maprotiline (MP, Ludiomil), N-acetylmaprotiline (AcMP) and N-acetyldesmethylmaprotiline (AcDMP) in whole blood or plasma. In two groups (A and B) of 82 and 53 depressive patients treated clinically with MP for 10 and 21 days, respectively, plasma and whole blood MP was monitored during the treatment. In group A, all subjects were phenotyped with debrisoquine and mephenytoin, and 44 with sulfamidine. 5 patients were poor metabolizers of debrisoquine and 2 of mephenytoin; 18 subjects were fast acetylators of sulfamidine. Traces of AcMP were found only in two patients. AcDMP was present in levels below 2 ng/ml in the plasma of most of the patients in group A. In group B, AcDMP levels between 2.4-14.6 ng/ml of whole blood were found in 9 patients. The mass spectral data suggest the presence of another, unknown MP metabolite interfering partly with the analysis of AcDMP. The presence of AcDMP seemed not to be related to the phenotype of the patients as determined by the pharmacogenetic tests.
PID Serval
serval:BIB_2EDCD9683583
PMID
Date de création
2021-01-12T15:16:30.727Z
Date de création dans IRIS
2025-05-20T17:49:40Z